26 January 2018 Prefrontal hemodynamic changes measured using near-infrared spectroscopy during the Valsalva maneuver in patients with orthostatic intolerance
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Abstract
The Valsalva maneuver (VM) with beat-to-beat blood pressure and heart rate monitoring are used to evaluate orthostatic intolerance (OI). However, they lack the ability to detect cerebral hemodynamic changes, which may be a cause of OI symptoms. Therefore, we utilized near-infrared spectroscopy during VM. Patients with OI symptoms and normal healthy subjects were recruited. Patients were subgrouped according to VM results: patients with normal VM (NVM) and abnormal VM (AbVM). Oxyhemoglobin (HbO), deoxyhemoglobin, and total hemoglobin changes were measured at four different source–detector distances (SD) (15, 30, 36, and 45 mm), and latency, amplitude, duration, and integrated total signal were calculated. Those parameters were compared between a normal healthy control (HC) group and the two OI patient subgroups. We found that HbO increment latency at 30-mm SD in the HC, NVM, and AbVM groups was as follows: 0.39±0.23  s, 2.79±0.36  s, and 8.14±0.55  s, respectively (p<0.05). Among the four parameters we evaluated, latency of HbO increment was the best marker for differentiating OI.
© 2018 Society of Photo-Optical Instrumentation Engineers (SPIE)
Yoo Hwan Kim, Yoo Hwan Kim, Zephaniah Phillips, Zephaniah Phillips, Seung-ho Paik, Seung-ho Paik, Nam-Joon Jeon, Nam-Joon Jeon, Beop-Min Kim, Beop-Min Kim, Byung-Jo Kim, Byung-Jo Kim, } "Prefrontal hemodynamic changes measured using near-infrared spectroscopy during the Valsalva maneuver in patients with orthostatic intolerance," Neurophotonics 5(1), 015002 (26 January 2018). https://doi.org/10.1117/1.NPh.5.1.015002 . Submission: Received: 20 July 2017; Accepted: 4 January 2018
Received: 20 July 2017; Accepted: 4 January 2018; Published: 26 January 2018
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