1 April 1974 Nuclear Medicine Imaging with Pressurized Multiwire Proportional Chambers
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Optical Engineering, 13(2), 132126 (1974). doi:10.1117/12.7971684
The pressurized xenon-filled multi-wire proportional chamber (MWPC) is an imaging detector with high intrinsic spatial resolution and good uniformity of response. We describe the design and operation of a 20 x 20 cm2 MWPC with a mass of 0.14 g/cm2 of xenon, maintained at 60 psi absolute. Electromagnetic delay-lines are used to obtain position information. Imaging studies have been performed using a Nuclear Chicago low-energy high-resolution collimator. The intrinsic resolution of the system was determined for 60 keV and 140 keV photons using bar phantoms, and was found to be 1 mm and 2 mm respectively. The Modulation Transfer Function for 140 keV is down to 70 percent response at 1.4 cycles per cm. Stopping-power is about 65 percent for 1-125 and 10 percent for Tc-99m. The distribution of thyroid hormones in the rat was clearly demonstrated. Picker thyroid phantoms filled with 1-125 and TC-99m were imaged with good detail. Preliminary 1-125 thyroid studies in humans have shown a promising potential. Other studies in rats have included liver/spleen imaging with Tc-99m-sulfur colloid and skeletal imaging with Tc-99m-polyphosphate. The excellent spatial resolution of the detector, together with the addition of higher efficiency collimators and operation at higher pressures realize a system with characteristics that are adequate for clinical use. These components are now being incorporated in a 30 x 30 cm2 MWPC.
Leon Kaufman, L. Blumin, R. Cavalieri, V. Perez-Mendez, Gerald Stoker, "Nuclear Medicine Imaging with Pressurized Multiwire Proportional Chambers," Optical Engineering 13(2), 132126 (1 April 1974). https://doi.org/10.1117/12.7971684

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