The fabrication of IR optical fibers for the 2- to 14-µm region is described. Both cylindrical and square fibers fabricated from rods and tubes are discussed. The physical properties of the GeSbSe glasses and optical fibers are reviewed. Fabrication of different fiber bundles is also reported. The applications of IR optical fibers and bundles are described, and system performance and parametric analyses are developed for some applications, including thermal imaging, IR sensors, CO2 laser power guide, and low-loss optical fibers.