The results of a research program on the delivery of high-peak-power laser light via fiber optics are presented. We discuss the influence of the host medium and the optical signals on the choice of fiber materials, complemented by a consideration of the measurement environment's effects on the quality of the data. We pay close attention to the choice of input/output beam/fiber coupling optics, nonlinear processes in the core, measurement system noise, and baseline drifts. Useful discussions of pulsed laser damage to optical fibers and data for optimization of a given fiber optic laser beam delivery system are given. As an example, details are given of the optical and instrumentational aspects of a particular fiber optic system developed for remote sensing of pressures and temperatures of UF6 gas in an operating advanced gas centrifuge.