Digital tomosynthesis involves tomographic motion about a single plane during which separate radiographs are acquired at equal angular increments. The resulting series of images can be shifted and recombined to yield planes in focus at any depth in the patient. Previous work has used image intensifiers for acquisition. However, conventional image intensifiers suffer from a limited field of view and from problems arising from the curved image input. The present work, which uses digitized 14 x 17 in. films, eliminates these problems in order to explore the potential for high resolution tomosynthesis of the chest. The method utilizes linear tomographic motion about one plane, acquiring films every 2.5° over a 50° arc. These 21 films are digitized with a laser scanner, registered to ±1 pixel accuracy, shifted, and added in order to generate images in any desired plane. These tomosynthesized images are then displayed on a 23-in. 1000-line monitor. Work has been directed specifically at chest imaging. A tomography phantom, an anthropomorphic chest phantom, and a dog have been imaged. In addition to the synthesis of tomographic planes, thin slice images with differential tissue emphasis have been accomplished. These tomograms in digital format readily lend themselves to image processing.