Refinements of holographic instruments for the First International Microgravity Laboratory Spaceflight, scheduled for February 1992, are described. The refinements include addition of holographic optical elements (HOEs) to incorporate tomographic analysis of the solution concentration and particle image displacement velocimetry to measure convection. A variety of advanced diagnostic instruments were designed for future spaceflights and possibly in the space station. These new instruments employ fiber optics, diode lasers, and HOEs to enhance miniaturization and ruggedness and to reduce power requirements. The instruments can measure concentration, temperature, convection, and crystal growth rate. Instruments currently in use as well as the conceptual designs and applications of future laser- and holography-based instrumentation are described.