1 February 1993 Beta carotene decreases total fluorescence from human arteries
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Abstract
The influence of β-carotene content on laser-induced total fluorescence is evaluated in vitro, using human arteries at 488-nm excitation. The investigation demonstrates that the β-carotene content in normal arteries increases with a longer period of incubation in β-carotene solution. This is associated with a decrease in the total fluorescence emission at 488-nm excitation. A decrease of 52% in the total fluorescence emitted from the arterial tissue is noted with the increased β-carotene deposition after incubation. The experimental data are highly correlated with theoretical analyses, derived by using the Kubelka-Munk and Lambert-Beer models, which incorporate parameters of β-carotene content in arterial tissue (r = 0.94 and r = 0.91 , respectively). Total fluorescence from 138 samples of various types of atherosclerotic plaques is compared with that from normal arteries used as controls. Total fluorescence gradually decreases with longer incubation periods in β-carotene solution. For all atherosclerotic plaques, the normalized fluorescence of 0.30 ± 0.16 at initial incubation decreases to 0.23 ± 0.12 after 6 d of incubation (p < 0.005). The value then decreases to 0.19 ± 0.10 after 12 d of incubation (p < 0.005 compared to the initial and 6 d of incubation). Seventy-nine plaques with surface fissures exhibited an accelerated reduction in total fluorescence when compared to nonfissured plaque.
Biqing Ye, George S. Abela, "Beta carotene decreases total fluorescence from human arteries," Optical Engineering 32(2), (1 February 1993). https://doi.org/10.1117/12.60696 . Submission:
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