Tissue characterization and imaging using photon density waves

Lars Othar Svaasand; Bruce J. Tromberg; Richard Campbell Haskell; Tsong-Tseh Tsay; Michael W. Berns

doi:10.1117/12.60749

1 February 1993 Tissue characterization and imaging using photon density waves

Lars Othar Svaasand, Bruce J. Tromberg, Richard Campbell Haskell, Tsong-Tseh Tsay, Michael W. Berns

Author Affiliations +

Optical Engineering, 32(2), (1993). https://doi.org/10.1117/12.60749

Abstract

The optical properties of brain tissues have been evaluated by measuring the phase velocity and attenuation of harmonically modulated light. The phase velocity for photon density waves at 650-nm wavelength has been found to be in the range of 5 to 12% of the corresponding velocity in a nonscattering medium, and the optical penetration depth was in the range 2.9 to 5.2 mm. These results are used to predictthe resolution of optical imaging of deep tissue structures by diffusely propagating incoherent photons. The results indicate that structures of a few millimeters in linear dimension can be identified at 10 mm depth provided that proper wavelength and time resolution are selected. This depth can possibly be enlarged to 30 mm in the case of tissues with very low scattering such as in the case of the neonatal human brain.

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Lars Othar Svaasand, Lars Othar Svaasand, Bruce J. Tromberg, Bruce J. Tromberg, Richard Campbell Haskell, Richard Campbell Haskell, Tsong-Tseh Tsay, Tsong-Tseh Tsay, Michael W. Berns, Michael W. Berns, } "Tissue characterization and imaging using photon density waves," Optical Engineering 32(2), (1 February 1993). https://doi.org/10.1117/12.60749 . Submission:

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