We present the design and fabrication of holographic diffusers for diffuse IR wireless home networking. Three optimization methods—error reduction, input-output, and simulated annealing—are studied and used to calculate the computer-generated holograms, which are employed to fabricate the holographic diffusers. To evaluate the performance of the computer-generated holograms generated using these techniques, a cost function is defined and calculated for each hologram. The computer-generated hologram generated from the simulated annealing is found to have the best output compared to the other two techniques. The diffusers are verified by displaying them onto a spatial light modulator. The fabrication of the computer-generated hologram onto a piece of quartz with a pixel size of 14×14 μm using a laser writing system is achieved, and the diffraction pattern of the diffuser is demonstrated.