In this study, we propose a pulsed Nd:YAG laser system that uses a sequential charge and discharge circuit to adhere polymethylmethacryl (PMMA) plastics. Two PMMA plastics adhere to each other when the red one transmits the laser beam and the black one absorbs it. The optimal adhesion depends on several process parameters, such as the charging voltage of the capacitor, the pulse rate [in pulses per second (pps)], the velocity of the target, and the laser beam diameter. We try to optimize the adhesion process parameters from trial-and-error experiments. It has proposed that the optimal adhesion process parameters are a charging voltage of 650 V, a pulse rate of 11 pps, a target velocity of 4.20 mm/s, and a laser beam diameter of 4.00 mm in this pulsed Nd:YAG laser system. In addition, we generalize the optimal conditions for plastic adhesion, such as energy per pulse, peak power, and the velocity of the target.