Fabrication of fiber-optic localized surface plasmon resonance sensor and its application to detect antibody-antigen reaction of interferon-gamma

Hyeon-Ho Jeong; Seung-Ki Lee; Jae-Hyoung Park; Norov Erdene; Dae-Hong Jeong

doi:10.1117/1.3662418

1 December 2011 Fabrication of fiber-optic localized surface plasmon resonance sensor and its application to detect antibody-antigen reaction of interferon-gamma

Hyeon-Ho Jeong, Seung-Ki Lee, Jae-Hyoung Park, Norov Erdene, Dae-Hong Jeong

Author Affiliations +

Optical Engineering, Vol. 50, Issue 12, 124405 (December 2011). https://doi.org/10.1117/1.3662418

Abstract

A fiber-optic localized surface plasmon (FO LSPR) sensor was fabricated by gold nanoparticles (Au NPs) immobilized on the end-face of an optical fiber. When Au NPs were formed on the end-face of an optical fiber by chemical reaction, Au NPs aggregation occurred and the Au NPs were immobilized in various forms such as monomers, dimers, trimers, etc. The component ratio of the Au NPs on the end-face of the fabricated FO LSPR sensor was slightly changed whenever the sensors were fabricated in the same condition. Including this phenomenon, the FO LSPR sensor was fabricated with high sensitivity by controlling the density of Au NPs. Also, the fabricated sensors were measured for the resonance intensity for the different optical systems and analyzed for the effect on sensitivity. Finally, for application as a biosensor, the sensor was used for detecting the antibody-antigen reaction of interferon-gamma.

©(2011) Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation Download Citation

Hyeon-Ho Jeong, Seung-Ki Lee, Jae-Hyoung Park, Norov Erdene, and Dae-Hong Jeong "Fabrication of fiber-optic localized surface plasmon resonance sensor and its application to detect antibody-antigen reaction of interferon-gamma," Optical Engineering 50(12), 124405 (1 December 2011). https://doi.org/10.1117/1.3662418

Published: 1 December 2011

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