We report on the optimization of precision optical component assemblies for space application with respect to mechanical resilience and retention of optical tolerances such as flatness and angles. Optimized parameters include: the cleaning method of the surfaces to be joined; type, concentration, and quantity of the chemical bonding agent; and post-bonding and curing conditions. Experimental studies and quality assurance are complicated by the large statistical spread in breaking stress, which requires the preparation of a large number of samples. The results previously reported in literature have focused primarily on fused silica, rather than space-qualifiable materials such as Zerodur® and ULE®, and have typically addressed only one or two of the parameters. This study provides a comprehensive picture and a better general understanding of what makes a bond reliably strong.