Development of silicon-on-insulator-based nanoporous silicon photonic crystals for label-free DNA detection

Xiaoyi Lv; Furu Zhong; Zhenhong Jia; Liangliang Chen; Ji Ma; Hongyan Zhang; Zhuangqi Cao; Jun Zhou

doi:10.1117/1.OE.52.6.064401

3 June 2013 Development of silicon-on-insulator-based nanoporous silicon photonic crystals for label-free DNA detection

Xiaoyi Lv, Furu Zhong, Zhenhong Jia, Liangliang Chen, Ji Ma, Hongyan Zhang, Zhuangqi Cao, Jun Zhou

Author Affiliations +

Optical Engineering, 52(6), 064401 (2013). https://doi.org/10.1117/1.OE.52.6.064401

Abstract

We fabricated a one-dimensional nanoporous silicon photonic crystal on a silicon insulator substrate by a cost-effective electrochemical method as an optical biosensor for the detection of DNA hybridization. In the first step, a transfer matrix method was used to calculate the corresponding reflectivity spectrum for the design of nanoporous silicon photonic crystals. Then silicon-on-insulator-based photonic crystals were prepared by a novel simple electrochemical etching. Genes were hybridized inside the porous silicon (PS) pores by aminopropyltriethoxysilane and glutaraldehyde and detected through frequency resolved reflectance measurements. A detection sensitivity of 17.445 nm/μM is demonstrated with good specific detection. The linear response range covers a concentration range of antifreeze protein gene from 0.625 to 10.000 μM. This high responsivity indicates that the silicon-on-insulator-based PS photonic crystal has significant potential for application in biological micro-electro-mechanical-systems technologies.

Citation Download Citation

Xiaoyi Lv, Xiaoyi Lv, Furu Zhong, Furu Zhong, Zhenhong Jia, Zhenhong Jia, Liangliang Chen, Liangliang Chen, Ji Ma, Ji Ma, Hongyan Zhang, Hongyan Zhang, Zhuangqi Cao, Zhuangqi Cao, Jun Zhou, Jun Zhou, } "Development of silicon-on-insulator-based nanoporous silicon photonic crystals for label-free DNA detection," Optical Engineering 52(6), 064401 (3 June 2013). https://doi.org/10.1117/1.OE.52.6.064401 . Submission:

ACCESS THE FULL ARTICLE

PERSONAL SIGN IN
Full access may be available with your subscription

Email or Username Forgot your username?

Password Forgot your password?

Show

Remember Email/Username on this computer

Remember Password

No SPIE account? Create an account
or Institutional Sign In via Shibboleth

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $20.00

Non-members: $25.00 ADD TO CART

Show All Keywords

Keywords/Phrases

Search In:

Publication Years