31 January 2014 Hyperemic responses of the optic nerve head blood flow to chromatic equiluminant flicker are reduced by ocular hypertension and early glaucoma
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Abstract
We evaluated in ocular hypertension (OHT) and early glaucoma (EOAG) patients the optic nerve head (ONH) blood flow response (RF onh ) to chromatic equiluminant flicker. This stimulus generates neural activity dominated by the parvo-cellular system. Eleven EOAG, 20 OHT patients, and 8 age-matched control subjects were examined. The blood flow (F onh ) at the neuroretinal rim was continuously monitored by laser Doppler flowmetry before, during, and after a 60-s exposure to a 4 Hz, red-green equiluminant flicker stimulus (30 deg field). RF onh was expressed as percentage F onh -change during the last 20 s of flicker relative to baseline F onh . Responses were collected at a number of temporal sites. The highest RF onh value was used for subsequent analysis. As compared to controls, both OHT and EOAG patients showed a decrease (p<0.01 ) in mean RF onh . We conclude that RF onh elicited by chromatic equiluminant flicker is abnormally reduced in OHT and EOAG patients indicating an impairment of the parvo-cellular-mediated vasoactivity. This decrease of vascular response may occur independently of neural activity loss early in the disease process.
© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
Benedetto Falsini, Benedetto Falsini, Charles E. Riva, Charles E. Riva, Tommaso Salgarello, Tommaso Salgarello, Eric Logean, Eric Logean, Alberto Colotto, Alberto Colotto, Andrea Giudiceandrea, Andrea Giudiceandrea, } "Hyperemic responses of the optic nerve head blood flow to chromatic equiluminant flicker are reduced by ocular hypertension and early glaucoma," Optical Engineering 53(6), 061706 (31 January 2014). https://doi.org/10.1117/1.OE.53.6.061706 . Submission:
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