25 March 2015 Numerical simulation validation of nonuniform, nonharmonic analysis of spectral-domain optical coherence tomography
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Abstract
In spectral-domain optical coherence tomography (SD-OCT), the limited resolution of the spectrometer causes nonuniformity of the interference signal. The latter, in turn, causes the sensitivity of SD-OCT to decrease, thereby limiting the imaging range and decreasing the axial resolution. We addressed this problem by applying nonuniform, nonharmonic analysis (NUNHA) with software that features high-frequency resolution without interpolation. We demonstrate the application of NUNHA in SD-OCT and compare it with conventional frequency analysis methods by simulating nonuniform interference signals. The results suggest that application of NUNHA in SD-OCT can provide acquisition of a clearer tomographic image, accurate analysis of fine and complex structures, and preservation of resolution and sensitivity at regions deep within a sample. This is because it reduces the influence of nonuniformity caused by the spectrometer and is unaffected by distortion due to interpolation.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
Tetsuya Uchida, Yuya Inuzuka, Masaya Hasegawa, Shigeki Hirobayashi, Tadanobu Misawa, "Numerical simulation validation of nonuniform, nonharmonic analysis of spectral-domain optical coherence tomography," Optical Engineering 54(3), 033108 (25 March 2015). https://doi.org/10.1117/1.OE.54.3.033108 . Submission:
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