We report the laser cooling performance of 5 mol. % Yb3+:LuLiF4 crystal in air. Both end faces of the crystal with a size of 3×3×5 mm3 are cut by Brewster angles. A temperature drop of 11 K (from room temperature) of the sample, pumped by a 3-W/1020-nm CW fiber laser, is observed by a thermal camera. The cooling power and efficiency of the sample are estimated to be ∼14.5 mW and ∼1.9%, respectively. Our experiment results show the prospect of this crystal with laser cooling and its potential applications in earth-based optical refrigeration devices.