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14 January 2020 Investigated spectral-fluorescent properties of endogenous porphyrins of the wild boar hepatobiliary system optimize the diagnostics and treatment of cholangiocarcinoma with FD and PDT
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Abstract

The combined use of fluorescence diagnostics (FD) and photodynamic therapy (PDT) is a promising approach to the treatment of cholangiocarcinoma. Information about the probing depth of laser radiation at a therapeutic dose sufficient for the appearance of the photodynamic effect allows planning the PDT process. We aim to assess the probing depth of radiation at a therapeutic dose. The highest fluorescence intensity is observed in the gall bladder and liver tissues. A significant difference was noted in the intensity of backscattered laser radiation, depending on the segments of the wild boar hepatobiliary system. Analysis of the probing depth of radiation (λ  =  660  nm) revealed that when the optical fiber is located outside the drainage, it increases by 2 to 4 mm, which improves the efficacy of treatment. The applicability of video FD of segments of the hepatobiliary system is investigated using the two-channel video fluorescence system. During video FD in the near-infrared range, the contrast of the fluorescence images of the hepatobiliary system is less than in the visible range. The results of the study will improve the quality of diagnostic information and optimize the FD and PDT algorithms for malignant neoplasms of the human hepatobiliary system.

© 2020 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2020/$28.00 © 2020 SPIE
Artem Shiryaev, Polina Alekseeva, Kanamat Efendiev, Dmitry Yakovlev, Arkadii Moskalev, Elizaveta Kozlikina, Pavel Kharnas, Igor Reshetov, Vladimir Levkin, and Victor Loschenov "Investigated spectral-fluorescent properties of endogenous porphyrins of the wild boar hepatobiliary system optimize the diagnostics and treatment of cholangiocarcinoma with FD and PDT," Optical Engineering 59(6), 061615 (14 January 2020). https://doi.org/10.1117/1.OE.59.6.061615
Received: 24 October 2019; Accepted: 23 December 2019; Published: 14 January 2020
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