1 September 1970 Automatic Recognition of White Blood Cells
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APPROACH TO DIFFERENTIATING AMONG WHITE BLOOD CELLS A problem of great importance in medicine is that of distinguishing among different types of white blood cells, or leucocvtes. Unlike the red blood cell, the white blood cell has a nucleus. The nucleus may be round in shape that is, can have a circular boundary as seen through the microscope - or it can be kidney-shaped, or it can have two, three, or more lobes, see Figure 1 a. The general theory is that a white blood cell starts out with a circular nucleus, which as the cell matures becomes kidney-shaped, and finally lobular, or Polymorphonuclear. Thus our problem becomes one of distinguishing among these shapes of nuclear boundaries.
Robert S. Ledley, George C. Cheng, "Automatic Recognition of White Blood Cells," Optical Engineering 8(6), 806209 (1 September 1970). https://doi.org/10.1117/12.7971522 . Submission:

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