Journal of Biomedical Optics

Editor-in-Chief: Brian W. Pogue, Dartmouth College

The Journal of Biomedical Optics (JBO) publishes peer-reviewed papers on the use of novel optical systems and techniques for improved health care and biomedical research.

Announcement: JBO will become a fully open access journal in January 2019. Beginning with submissions received on or after 1 July 2018, authors of accepted papers will be required to pay an article processing charge of $1675. Discounts may apply.

Calls for Papers
How to Submit to a Special Section

To submit a manuscript for consideration in a special section, please prepare the manuscript according to the journal guidelines and use the Online Submission SystemLeaving site. A cover letter indicating that the submission is intended for this special section should be included with the paper. Papers will be peer‐reviewed in accordance with the journal's established policies and procedures. Authors have the choice to publish with open access.

Announcement: JBO will become a fully open access journal in January 2019. Beginning with submissions received on or after 1 July 2018, authors of accepted papers will be required to pay an article processing charge of $1675. Discounts may apply.

Biomedical Imaging and Sensing
Publication Date
Special section papers are published as soon as the copyedited and typeset proofs are approved by the author.
Submission Deadline
Manuscripts due 1 July 2018.
Guest Editors
Toyohiko Yatagai, PhD

Utsunomiya University, Japan
E-mail: yatagai@cc.utsunomiya-u.ac.jp

Osamu Matoba, PhD

Kobe University, Japan
E-mail: matoba@kobe-u.ac.jp 

Yoshihisa Aizu, PhD

Muroran Institute of Technology, Japan
E-mail: aizu@mmm.muroran-it.ac.jp 

Yasuhiro Awatsuji, PhD

Kyoto Institute of Technology, Japan
E-mail: awatsuji@kit.ac.jp 

Yuan Luo, PhD

National Taiwan University, Taiwan
E-mail: yuanluo@ntu.edu.tw

Scope

In biomedical optics and photonics, optical tools are employed for the understanding and treatment of diseases, from the cellular level to macroscopic applications. At the cellular level, highly precise laser applications allow the manipulation, operation, or stimulation of cells, even in living organisms or animals. Optical microscopy has been revolutionized by a thorough understanding of the different markers and their switching behavior.

Marker-free microscopy technologies, like coherent anti-Stokes Raman scattering, second-harmonic generation, third-harmonic generation microscopy, or digital holographic microscopy are spreading into multiple biological and clinical imaging applications. OCT is continuously broadening its clinical applicability by becoming even higher resolution, higher speed, and more compact. In the broader field of optics and photonics, biomedical imaging and sensing are the most quickly progressing and expanding areas. Techniques developed in these areas could greatly advance physical, engineering, and biological knowledge as well as optics and photonics technology.

This special section on biomedical imaging and sensing will be devoted to advanced biomedical imaging and sensing techniques.

  • advanced microscopy
  • advanced endoscopy
  • superresolution in biomedical imaging and sensing
  • computational imaging in biomedical imaging and sensing
  • adaptive optics in biomedical imaging and sensing
  • structured illumination in biomedical imaging and sensing
  • interferometry and holography in biology and medicine
  • optical coherence tomography
  • diffuse optical tomography
  • digital holography
  • quantitative phase imaging
  • photoacoustic imaging
  • multimodal imaging and sensing
  • optical biopsy
  • spectroscopic imaging and sensing
  • multispectral imaging and sensing
  • scattering imaging
  • fluorescence imaging
  • molecular imaging
  • terahertz sensing
  • optical fibers and sensors for biomedicine
  • multimodality optical diagnostic systems.

All submissions will be peer reviewed. Peer review will commence immediately upon manuscript submission, with a goal of making a first decision within 6 weeks of manuscript submission. Special sections are opened online once a minimum of four papers have been accepted. Each paper is published as soon as the copyedited and typeset proofs are approved by the author. Submissions should follow the guidelines of JBO. Manuscripts should be submitted online at https://jbo.msubmit.net. A cover letter indicating that the submission is intended for this special section should be included.

Laser-Tissue Interaction and Optical Properties of Biological Tissues: Honoring Prof. Steven Jacques, a Pioneer in Biomedical Optics
Publication Date
Special section papers are published as soon as the copyedited and typeset proofs are approved by the author.
Submission Deadline
Manuscripts due 1 July 2018.
Guest Editors
Jessica Ramella-Roman, PhD

Florida International University
Department of Biomedical Engineering
Miami, Florida, United States
E-mail: jessica.ramella@fiu.edu

Andreas Hielscher, PhD

Columbia University
Biomedical Engineering Department
New York, New York, United States
E-mail: ahh2004@columbia.edu

Lihong V. Wang, PhD

California Institute of Technology
Department of Medical Engineering and Electrical Engineering
Optical Imaging Laboratory
Pasadena, California, United States
E-mail: lihong@caltech.edu

Scope

Dr. Steven L. Jacques’ interest in biophotonics started early during his PhD at Berkley (1984) and postdoc at the Wellman Center for Photomedicine at Massachusetts General Hospital, where he studied the distribution of water in the stratum corneum of human skin. During the following years, he and his collaborators were instrumental in defining some of the most fundamental tools of this field, such as the determination of optical properties of many biological tissues, and Monte Carlo models of light transfer in biological environments. He is known for being a passionate and effective communicator, and his lectures in the fundamentals of biophotonics and the website he compiled with Scott Prahl (omlc.org) have been used by thousands of researchers all over the world and remain an excellent reference for anybody beginning studies in the field. He was also one of the first researchers in our community to collaborate with scientists in China, most notably the Britton Chance Center of Medical Photonics in Wuhan, where he was a frequent visitor and collaborator.

Dr. Jacques’ work spans several biomedical optics disciplines, which is a testament to his curiosity as a scientist. He developed handheld systems to noninvasively measure hyperbilirubinemia in newborns, which are now in use in neonatal care. Most recently, he has worked in polarization-based imaging of skin cancer and in vivo sub-nm measurements of vibration of the cochlear membrane of the inner ear.

This particular special section is intended to honor Prof. Steve Jacques’ contribution to biomedical optics and will focus on the following main topics:

Tissue optics
As the biomedical optics field moves into new clinical applications, an increasingly accurate determination of optical tissue properties is necessary for the development of new modalities and to understand pathological conditions. Novel instrumentation and models for the determination of biological optical properties are necessary, as well as a better understanding of variation in human versus animal tissue optical properties. This accurate determination is indispensable to the development of new optical phantoms for the characterization of novel optical modalities.

Models of light transfer
Biomedical instrumentations based on optical principles are entering the clinical environment at a rapid pace. Models of light propagation in tissue are necessary to meet the requirements in clinical setting for accuracy and speed. Parallelized inverse Monte Carlo models, radiative transport theory and diffusion approximation, as well as ad hoc models and big data models cover a broad range of clinical situations and applications. Furthermore, novel models that include a complete array of tissue properties (spectral, mechanical/acoustic, etc.) and models that can deal with a vast array of optical radiation properties such as coherence and polarization are of great interest.

Polarized light imaging and sensing for biomedical applications
Dr. Jacques’ pioneering work in skin polarimetry has opened new areas of research in biophotonics, and the use of polarized imaging and sensing in clinical and preclinical applications is quickly expanding. Novel modalities such as polarization sensitive optical coherence tomography (PS-OCT) and Mueller matrix polarimetry are yielding new insights on tissue structure and mechanical properties. Faster imaging strategies, novel calibration techniques, and new inverse models are needed to bring these modalities to the clinical setting.

Novel approaches in mentoring and education in biophotonics
Dr. Jacques’ passion for mentoring has helped many students and researchers over the years. Together with Scott Prahl, he was one of the first educators to post online lectures on the principles of biophotonics at a time when academic books on the topic were not available. His website omlc.org has reached a sizeable web-based audience and is now fostering the education of many future biophotonics scientists. New education paradigms are needed to improve the generational transfer of knowledge utilizing novel educational strategies and technological advances.

Contributed Papers
In addition to the above-mentioned topics, areas of interest for this special section include, but are not limited to:

  • Biomedical optical spectroscopy and imaging: systems and applications
  • Photoacoustic tomography or microscopy, acousto-optical imaging
  • Microscopic tools for in vivo imaging.

All submissions will be peer reviewed. Peer review will commence immediately upon manuscript submission, with a goal of making a first decision within 6 weeks of manuscript submission. Special sections are opened online once a minimum of four papers have been accepted. Each paper is published as soon as the copyedited and typeset proofs are approved by the author. Submissions should follow the guidelines of JBO. Manuscripts should be submitted online at https://jbo.msubmit.net. A cover letter indicating that the submission is intended for this special section should be included.

Steve Jacques
Translational Biophotonics
Publication Date
Special section papers are published as soon as the copyedited and typeset proofs are approved by the author.
Submission Deadline
Manuscripts due 1 June 2018.
Guest Editors
Bruce J. Tromberg, PhD

Beckman Laser Institute
Irvine, California
E-mail: bjtrombe@uci.edu

Gabriela Apiou, PhD

Harvard Medical School
Massachusetts General Hospital
Wellman Center for Photomedicine
Boston, Massachusetts
E-mail: gapiou@mgh.harvard.edu

Markus Kleemann, MD

University Schleswig-Holstein
Department of Vascular Surgery
Luebeck, Germany
E-mail: Markus.Kleemann@uk-sh.de

Regine Choe, PhD

University of Rochester
Department of Biomedical Engineering
Rochester, New York 14627
E-mail: regine_choe@urmc.rochester.edu

Scope

In 2018, the Journal of Biomedical Optics invites contributions for the third annual special section based on the papers presented at SPIE BiOS Translational Research Symposium at Photonics West. This symposium highlights the unique challenges associated with translating biophotonics technologies from benchtop to bedside. This special section is intended to complement the Translational Research Symposium by providing archival, peer-reviewed manuscripts that describe technologies and best practices that will further accelerate the translation of biophotonics research into clinical practice.

Papers should demonstrate how optics and photonics technologies can be used to solve healthcare challenges, including improving clinical outcome, and enhancing cost-effectiveness. A range of topics will be explored, spanning from early phase feasibility studies to emerging strategies for disease detection, diagnosis, treatment, and prevention.

Key concepts that will be addressed include:

  • Identifying clinical problems and unmet clinical needs
  • Matching biophotonics solutions to clinical problems
  • Developing clinical outcome measure(s) to assess efficacy
  • Describing operational barriers to clinical translation
  • Disseminating and adopting biophotonics technologies.

All submissions will be peer reviewed. Peer review will commence immediately upon manuscript submission, with a goal of making a first decision within 6 weeks of manuscript submission. Special sections are opened online once a minimum of four papers have been accepted. Each paper is published as soon as the copyedited and typeset proofs are approved by the author. Submissions should follow the guidelines of JBO. Manuscripts should be submitted online at https://jbo.msubmit.net. A cover letter indicating that the submission is intended for this special section should be included.

Translational Biophotonics
Spatial Frequency Domain Imaging
Publication Date
Special section papers are published as soon as the copyedited and typeset proofs are approved by the author.
Submission Deadline
Manuscripts due 1 September 2018.
Guest Editors
David Cuccia, PhD

Modulated Imaging, Inc.
Irvine, California
E-mail: david.cuccia@modulatedimaging.com

Sylvain Gioux, PhD

University of Strasbourg
Strasbourg, France
E-mail: sgioux@unistra.fr

Amaan Mazhar, PhD

Modulated Imaging, Inc.
Irvine, California
E-mail: amaan.mazhar@modulatedimaging.com

Scope

In the field of diffuse optics, rapid quantitative imaging of living tissue samples over wide fields of view has been a topic of great interest and potential. For a long time, strategies typically consisted of one of the following: 1) raster-scanning the field of view with a point source, with challenges for rapid imaging, or 2) "full-frame" imaging methods which typically required empirical assumptions about tissue optical properties. More recently, the emergence of spatial frequency domain methods in diffuse and quasi-diffuse regimes has created new opportunities to quantitatively characterize tissues. In particular, spatial frequency domain imaging (SFDI) has enabled rapid characterization of large areas of tissue. Because of the multiplexing advantages provided by light projector instrumentation, SFDI measurements can typically characterize all the pixels within a camera image--virtually any field-of-view can be measured quantitatively and rapidly. Additionally, SFDI can be easily combined with other diffuse optical approaches, including fluorescence, polarization, and multispectral imaging modalities. Consequently, this method has generated enthusiasm and witnessed rapid growth, allowing many new innovations in the fields of biology and medicine.

The principles of this method are 20 years old, and the earliest imaging applications just over 10 years old. This special section will be devoted to the latest advances in instrumentation and application development of SFDI and related spatial frequency domain modalities. Appropriate topics include, but are not limited to:

  • diffuse optical imaging
  • diffuse optical tomography
  • microscopy
  • fluorescence imaging
  • instrumentation
  • acquisition methods
  • processing methods
  • preclinical applications
  • clinical applications
  • clinical translation.

All submissions will be peer reviewed. Peer review will commence immediately upon manuscript submission, with a goal of making a first decision within 6 weeks of manuscript submission. Special sections are opened online once a minimum of four papers have been accepted. Each paper is published as soon as the copyedited and typeset proofs are approved by the author. Submissions should follow the guidelines of JBO. Manuscripts should be submitted online at https://jbo.msubmit.net. A cover letter indicating that the submission is intended for this special section should be included.

SFDI
Metabolic Imaging and Spectroscopy: Britton Chance 105th Birthday Commemorative
Publication Date
Special section papers are published as soon as the copyedited and typeset proofs are approved by the author.
Submission Deadline
Manuscripts due 15 August 2018.
Guest Editors
Lin Z. Li, PhD

University of Pennsylvania
Perelman School of Medicine
Philadelphia, Pennsylvania, USA
linli@pennmedicine.upenn.edu

Arjun G. Yodh, PhD

University of Pennsylvania
Department of Physics and Astronomy
Philadelphia, Pennsylvania, USA
yodh@physics.upenn.edu

Scope

Britton Chance

June 11-13th 2018 marks the Second Britton Chance International Symposium on Metabolic Imaging/Spectroscopy at University of Pennsylvania honoring the memory of Professor Britton Chance (1913-2010). Britton Chance was a prolific and legendary scientist who made pioneering contributions in the fields of radar, biochemistry, and biophysics, and who was a founding father of in vivo NMR and biomedical photonics. His research activities spanned physics, chemistry, engineering, biology, and medicine with aims to generate new understanding about tissue function and disease, and dreams to impact health science and clinical translation.

This special section of the Journal of Biomedical Optics welcomes submissions on topics in this spirit, e.g., focused on biomedical photonics and optical imaging/spectroscopy of tissue metabolism and related concepts.

A range of topics can be explored, spanning from technical development, translation and clinical application of metabolic/functional imaging, and spectroscopy methods for disease detection, diagnosis, treatment, and prevention.

Some relevant topics include:

  • Instrumentation and technical development of metabolic imaging/spectroscopic methods
  • Imaging metabolism and functions of normal and diseased tissues
  • Methods and applications for disease diagnosis and treatment
  • Methods and applications for understanding physiology and biology
  • Metabolic imaging/spectroscopy of cells or tissues.

To ensure a timely publication we require all authors to submit their articles by Aug. 15, 2018.  Authors should refer to the formatting and submission guidelines described in the online Authors Guidelines. Manuscripts should be submitted online at https://jbo.msubmit.net. A cover letter indicating that the submission is intended for this special section should be included.

All submissions will be peer reviewed. Peer review will commence immediately upon manuscript submission, with a goal of making a first decision within 6 weeks of manuscript submission. Special sections are opened online once a minimum of four papers have been accepted. Each paper is published as soon as the copyedited and typeset proofs are approved by the author.

Previously Published Special Sections

Topical Problems of Biophotonics: from Optical Bioimaging to Clinical Biophotonics (September 2018)
Guest Editors: Mikhail Kirillin, Kirill Larin, Ilya Turchin, and Valery Tuchin

Selected Topics in Biophotonics: Optogenetics and Label-Free Optical Spectroscopy (April 2018)
Guest Editors: Stefan Andersson-Engels and Peter E. Andersen

White Papers in Biophotonics (February 2018)
Guest Editor: David Sampson

25 years of OCT (December 2017)
Guest Editors: David Sampson, Peter Andersen, Ton van Leeuwen, and Ricky Wang

Translational Biophotonics (December 2017)
Guest Editors: Guest Editors: Bruce Tromberg, Gabriela Apiou, Darren Roblyer, and Aaron Aguirre

Advanced Laser Technologies for Biophotonics (September 2017)
Guest Editors: Martin J. Leahy, Tia E. Keyes, Valery V. Tuchin, and Alexander V. Priezzhev

Photoacoustic Imaging and Sensing (April 2017)
Guest Editors: Mark A. Anastasio, Paul C. Beard, and Qing Zhu

Translational Biophotonics (2016)
Guest Editors: Bruce Tromberg, Gabriela Apiou, Kristen Kelly, and Conor L. Evans

Adaptive Optics and Wavefront Control for Biological Systems (December 2016)
Guest Editors: Thomas G. Bifano, Joel A. Kubby, and Sylvain Gigan

Optical Diagnostic and Biophotonic Methods from Bench to Bedside (October 2016)
Guest Editors: Amir Gandjbakhche, Bruce Tromberg, Israel Gannot, Jana M. Kainerstorfer, and Fatima Chowdhry

Clinical Near-Infrared Spectroscopy and Imaging (September 2016)
Guest Editors: Marco Ferrari, Joseph P. Culver, Yoko Hoshi, and Heidrun Wabnitz

Tissue and Blood Optical Clearing for Biomedical Applications (August 2016)
Guest Editors: Dan Zhu, Bernard Choi, Elina Genina, Valery V. Tuchin

Polarized Light for Biomedical Applications (July 2016)
Guest Editors: Igor Meglinski, Tatiana Novikova, Jessica C. Ramella-Roman, and Valery V. Tuchin

Selected Topics in Biophotonics: Photoacoustic Tomography and Fiber-Based Lasers and Supercontinuum Sources (June 2016)
Guest Editors: Stefan Andersson-Engels and Peter E. Andersen

Optical Medical Imaging Standards (December 2015)
Guest Editors: David W. Allen, Maritoni Litorja, and Jeeseong Hwang

Quantitative Phase Imaging in Biomedicine (November 2015)
Guest Editors: Gabriel Popescu and YongKeun Park

Protein Photonics for Imaging, Sensing, and Manipulation: Honoring Prof. Osamu Shimomura, a Pioneer of Photonics for Biomedical Research (October 2015)
Guest Editors: Katsumasa Fujita, Takeharu Nagai, Nathan Shaner, and Alexnader Egner

Light for Life: International Year of Light 2015 (June 2015)
Guest Editors: Rainer Leitgeb, Katarina Svanberg, Nimmi Ramanujam, Jürgen Popp, and Peter Andersen

Laser Applications in Life Sciences (May 2015)
Guest Editors: Alexander V. Priezzhev, Herbert Schneckenburger, and Valery V. Tuchin

Vibrational Spectroscopy and Imaging (November 2014)
Guest Editors: Anita Mahadevan-Jansen, Michael D. Morris, and Wolfgang Petrich

Biomimetic and Bioinspired Materials for Applications in Biophotonics (October 2014)
Guest Editors: Bahman Anvari, Pablo del Pino, Vikas Kundra, and Wolfgang Parak

Selected Topics in Biophotonics: Optical Coherence Tomography and Biomolecular Imaging with Coherent Raman Scattering Microscopy (July 2014)
Guest Editors: Stefan Andersson-Engels and Peter E. Andersen

Nanobio-Based Optical Sensing and Imaging (May 2014)
Guest Editors: Min-Gon Kim, Woo Keun Song, Kun Ho Lee, and Bahman Anvari

Optical Coherence Tomography and Interferometry: Advanced Engineering and Biomedical Applications (February 2014)
Guest Editors: Valery V. Tuchin, Kirill V. Larin, and Alex Vitkin

Advanced Biomedical Imaging and Sensing (January 2014)
Guest Editors: Chi-Kuang Sun, Arthur Chiou, Fu-Jen Kao, Chien Chou, and Chen-Yuan Dong

Special Section on Optical Elastography and Measurement of Tissue Biomechanics (December 2013)
Guest Editors: Ruikang K. Wang, David D. Sampson, Stephen A. Boppart, and Brendan F. Kennedy

Optical Imaging, Sensing, and Light Interactions in Cells and Tissues (November 2013)
Guest Editors: Natan T. Shaked, Shy Shoham, Bruce J. Tromberg, and Israel Gannot

Special Section on Fluorescence Molecular Imaging Honoring Prof. Roger Tsien, a Pioneer in Biomedical Optics (October 2013)
Guest Editors: Vasilis Ntziachristos, Samuel Achilefu, Yingxiao Peter Wang, and Michael Lin

Optical Methods of Imaging in the Skin (June 2013)
Guest Editor: Jürgen Lademann

Multiphoton Microscopy: Technical Innovations, Biological Applications, and Clinical Diagnostics (March 2013)
Guest Editors: Paul J. Campagnola, Chen-Yuan Dong, Karsten Koenig, Jerome Mertz, Peter T. C. So, Chris Xu

Laser Technologies for Biomedical Applications (October 2012)
Guest Editors: Ekaterina Borisova, Herbert Schneckenburger, Alexander Priezzhev

Optical Diagnostic and Biophotonic Methods from Bench to Bedside (August 2012)
Guest Editors: Amir Gandjbakhche, Jana M. Kainerstorfer, and Bruce Tromberg

Selected Topics in Biophotonics: Optical Coherence Tomography and Medical Imaging Using Diffuse Optics (July 2012)
Guest Editors: Stefan Andersson-Engels and Peter E. Andersen

Photoacoustic Imaging and Sensing (June 2012)
Guest Editors: Mark A. Anastasio and Paul C. Beard

Endomicroscopy Technologies and Biomedical Applications (February 2012)
Guest editors: Xingde Li and Warren S. Grundfest

FRET at 65 (January 2012)
Guest editors: Ammasi Periasamy, Steven S. Vogel, and Robert M. Clegg

Hard-Tissue Optics and Related Methods (July 2011)
Guest editors: Daniel Fried, Andreas Mandelis, and Michael Morris

Photonics and Nanotechnology in Biophysics and Biomedical Research (May 2011)
Guest editors: Bahman Anvari, Raoul Kopelman, and Luke P. Lee

Coherent Raman Imaging Techniques and Biomedical Applications (February 2011)
Guest editors: Eric O. Potma, Ji-Xin Cheng, and X. Sunney Xie

Pioneers in Biomedical Optics: Michael Feld (January 2011)
Guest Editors: Ramachandra Dasari, Rebecca Richards-Kortum, and Andrew Berger

Optical Diagnostic and Biophotonic Methods from Bench to Bedside (November/December 2010)
Guest Editors: Amir Gandjbakhche, Bruce Tromberg, and Jana Maria Kainerstorfer

Pioneers in Biomedical Optics: Prof. Tayyaba Hasan (September/October 2010)
Guest Editors: Brian W. Pogue, Georges A. Wagnieres, and Lothar D. Lilge

Selected Topics in Biophotonics: Photodynamic Therapy and Optical Micromanipulation for Biophotonics (July/August 2010)
Guest Editors: Stefan Andersson-Engels and Peter E. Andersen

Photons Plus Ultrasound: Imaging and Sensing (March/April 2010)
Guest Editors: Lihong V. Wang and Alexander A. Oraevsky

Optical Methods in Vascular Biology and Medicine (January/February 2010)
Guest Editors: Bernard Choi, Brett Bouma, Dai Fukumura, and Rakesh K. Jain

Nanophotonics for Diagnostics, Protection, and Treatment of Cancer and Inflammatory Diseases (March/April 2009)
Guest Editors: Valery V. Tuchin, Rebekah Drezek, Shuming Nie, and Vladimir P. Zharov

Selected Topics in Biophotonics: Diffuse Optics and Optical Molecular Imaging (July/August 2008)
Guest Editors: Stefan Andersson-Engels and Peter E. Andersen

Visible Fluorescent Proteins (May/June 2008)
Guest Editors: Alberto "Alby" Diaspro and Ammasi Periasamy

Optical Clearing of Tissues and Cells (March/April 2008)
Guest Editors: Valery V. Tuchin, Ruikang K. Wang, and Alvin T. Yeh

Small-Animal Optical Imaging (January/February 2008)
Guest Editors: Vasilis Ntziachristos, Joseph P. Culver, and Bradley W. Rice

Pioneers in Biomedical Optics: Honoring F.F. Jobsis (November/December 2007)
Guest Editors: David T. Delpy, Marco Ferrari, Claude A. Piantadosi, and Mamoru Tamura

Optical Diagnostic Imaging from Bench to Bedside (September/October 2007)
Guest Editors: Amir Gandjbakhche and Abby Vogel

Optical Coherence Tomography in Ophtalmology (July/August 2007)
Guest Editors: Wolfgang Drexler and James G. Fujimoto

Photonics in the Auditory System (March/April 2007)
Guest Editors: Bahman Anvari, William E. Brownell, Dennis M. Freeman, and Mats Ulfendahl

Pioneers in Biomedical Optics: Honoring Professor Ashley J. Welch (July/August 2006)
Guest Editors: E. Duco Jansen and Sohi Rastegar

Cardiovascular Photonics (March/April 2006)
Guest Editors: Laura Marcu, Guillermo J. Tearney, and Kenton W. Gregory

Optical Diagnostic Imaging from Bench to Bedside (September/October 2005)
Guest Editors: Amir Gandjbakhche and Israel Gannot

Chemical and Genetic Sensors in Biomedical Research (July/August 2005)
Guest Editors: Samuel Achilefu, Christopher H. Contag, Alexander P. Savitsky, and Ralph Weissleder

Infrared and Raman Spectroscopy (May/June 2005)
Guest Editors: Michael D. Morris, Andrew Berger, and Anita Mahadevan-Jansen

Optics in Neuroscience (January/February 2005)
Guest Editors: David A. Boas, Ph.D. and Ron D. Frostig, Ph.D.

Optics in Breast Cancer (November 2004)
Guest Editors: Sergio Fantini, Ph.D., K. Thomas Moesta, M.D., and Brian W. Pogue, Ph.D.

Pioneers in Biomedical Optics: Prof. Watt Webb (September 2004)
Guest Editors: David W. Piston and Elliott Elson

Biomedical Optics and Women's Health (May 2004)
Guest Editors: Rebecca Richards-Kortum and Michele Follen

Optics of the Human Skin (March 2004)
Guest Editor: J. Stuart Nelson

Ophthalmic Diagnostics (January 2004)
Guest Editors: Rafat R. Ansari and J. Sebag

Multiphoton Microscopy (July 2003)
Guest Editors: Ammasi Periasamy Ph.D. and Alberto Diaspro Ph.D.

Tools for Biomolecular and Cellular Analysis (October 2002)
Guest Editors: Richard B. Thompson and Fran Ligler

Tissue Polarimetry (July 2002)
Guest Editors: Lihong V. Wang, Gerard L. Coté, and Steven L. Jacques

Optical Imaging and Spectroscopy: From Benchtop to Bedside (January 2002)
Guest Editors: Amir H. Gandjbakhche, Michael Patterson, and Michele Follen

Frontiers in Microscopy (July 2001)
Guest Editors: M. J. Booth and T. Wilson

Advances in Contrast Agents, Reporters, and Detection (April 2001)
Guest Editors: Darryl J. Bornhop, Christopher H. Contag, Kai Licha, and Catherine J. Murphy

Continuation of Special Issue Honoring Professor Britton Chance (July 2000)
Special Issue Honoring Professor Britton Chance (April 2000)
Guest Editors: Arjun G. Yodh and Bruce J. Tromberg

Medical Near-Infrared Spectroscopy (October 1999)
Guest Editors: Kazuo Okada and Takafumi Hamaoka

Photodynamic Therapy (July 1999)
Guest Editors: Piotr Ziókowski, Krzysztof Symonowicz, Beata J. Osiecka, Jerzy Rabczyski, and Jerzy Gerber

Biomedical Applications of Vibrational Spectroscopic Imaging (January 1999)
Guest Editor: Michael D. Morris

Optical Diagnostics of Biological Fluids (January 1999)
Guest Editors: Alexander V. Priezzhev and Toshimitsu Asakura

Coherence Domain Optical Methods in Biomedical Science and Clinics (January 1999)
Guest Editors: Valery V. Tuchin, Halina Podbielska, and Christoph K. Hitzenberger

Interferometry in Biomedicine: part 2 (July 1998)
Interferometry in Biomedicine: part 1 (January 1998)
Guest Editors: Halina Podbielska, Christoph K. Hitzenberger, and Valery V. Tuchin

Near Infrared Spectroscopy and Imaging of Tissues (October 1996)
Guest Editors: Marco Ferrari, David T. Delpy, and David A. Benaron

Light Scatter and Fluorescence of the Eye Lens (July 1996)
Guest Editor: Barbara K. Pierscionek

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