CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 13 > Issue 5 > Article
Open Access
1 September 2008 Optical biopsy of early gastroesophageal cancer by catheter-based reflectance-type laser-scanning confocal microscopy
Madoka Nakao M.D., Shigeto Yoshida M.D., Shinji Tanaka M.D., Yoshito Takemura M.D., Shiro Oka M.D., Masaharu Yoshihara M.D., Kazuaki Chayama M.D.
Author Affiliations +
Journal of Biomedical Optics, Vol. 13, Issue 5, 054043 (September 2008). https://doi.org/10.1117/1.2983674
Abstract
Magnified endoscopic observation of the gastrointestinal tract has become possible. However, such observation at the cellular level remains difficult. Laser-scanning confocal microscopy (LCM) is a novel, noninvasive optical imaging method that provides instant microscopic images of untreated tissue under endoscopy. We compare prototype catheter-based reflectance-type LCM images in vivo and histologic images of early gastroesophageal cancer to assess the usefulness of LCM in diagnosing such cancer. 20 sites in the esophagus and 40 sites in the stomach are examined by LCM under endoscopy prior to endoscopic or surgical resection. A prototype catheter LCM system, equipped with a semiconductor laser that oscillates at 685 nm and analyzes reflected light (Mauna Kea Technologies, Paris, France; Fujinon, Saitama, Japan) is used in vivo without fluorescent agent. In all normal esophageal mucosa and esophageal cancers, the nuclei are visualized. In nine of the ten normal esophageal mucosa, cell membranes are visualized, and in five of the ten esophageal cancers, cell membranes are visualized. In all normal gastric mucosa, nuclei and cell membranes are not visualized, but in ten of the 20 gastric cancers, nuclei are visualized. This novel method will aid in immediate diagnosis under endoscopy without the need for biopsy.
©(2008) Society of Photo-Optical Instrumentation Engineers (SPIE)
Citation Download Citation
Madoka Nakao M.D., Shigeto Yoshida M.D., Shinji Tanaka M.D., Yoshito Takemura M.D., Shiro Oka M.D., Masaharu Yoshihara M.D., and Kazuaki Chayama M.D. "Optical biopsy of early gastroesophageal cancer by catheter-based reflectance-type laser-scanning confocal microscopy," Journal of Biomedical Optics 13(5), 054043 (1 September 2008). https://doi.org/10.1117/1.2983674
Published: 1 September 2008
JOURNAL ARTICLE
 5 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 21 scholarly publications.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Cancer
Endoscopy
Visualization
Biopsy
Confocal microscopy
Stomach
In vivo imaging
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top