Photoacoustic technique for assessing optical scattering properties of turbid media

Janaka C. Ranasinghesagara; Yan Jian; Xuhui Chen; Kory Mathewson; Roger J. Zemp

doi:10.1117/1.3200922

1 July 2009 Photoacoustic technique for assessing optical scattering properties of turbid media

Janaka C. Ranasinghesagara, Yan Jian, Xuhui Chen, Kory Mathewson, Roger J. Zemp

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Journal of Biomedical Optics, Vol. 14, Issue 4, 040504 (July 2009). https://doi.org/10.1117/1.3200922

Abstract

Measurement of tissue optical properties impacts both optical diagnostic and theraputic applications. Although existing photoacoustic imaging techniques provide optical absorption contrast, we present a photoacoustic technique that demonstrates sensitivity to the optical scattering coefficient of a turbid medium. By incrementing the distance between a surface illumination spot and a subsurface absorber and measuring the photoacoustic amplitude of the absorber, we can effectively estimate the Green's function of light transport in a turbid medium. Our results for different concentrations of Intralipid indicate that this technique has the ability to distinguish small changes of the reduced scattering coefficient. It has the potential to be used for in vivo studies to obtain reduced scattering coefficients of biological tissues. These findings will potentially improve the calculation of subcutaneous fluence in photoacoustic-based techniques and laser dosimetry studies in live tissues.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Janaka C. Ranasinghesagara, Yan Jian, Xuhui Chen, Kory Mathewson, and Roger J. Zemp "Photoacoustic technique for assessing optical scattering properties of turbid media," Journal of Biomedical Optics 14(4), 040504 (1 July 2009). https://doi.org/10.1117/1.3200922

Published: 1 July 2009

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