Efficient postacquisition synchronization of 4-D nongated cardiac images obtained from optical coherence tomography: application to 4-D reconstruction of the chick embryonic heart

Aiping Liu; Ruikang K. Wang; Kent L. Thornburg; Sandra Rugonyi

doi:10.1117/1.3184462

1 July 2009 Efficient postacquisition synchronization of 4-D nongated cardiac images obtained from optical coherence tomography: application to 4-D reconstruction of the chick embryonic heart

Aiping Liu, Ruikang K. Wang, Kent L. Thornburg, Sandra Rugonyi

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Journal of Biomedical Optics, Vol. 14, Issue 4, 044020 (July 2009). https://doi.org/10.1117/1.3184462

Abstract

Four-dimensional (4-D) imaging of the embryonic heart allows study of cardiac morphology and function in vivo during development. However, 4-D imaging of the embryonic heart using current techniques, including optical coherence tomography (OCT), is limited by the rate of image acquisition. Here, we present a nongated 4-D imaging strategy combined with an efficient postacquisition synchronization procedure that circumvents limitations on acquisition rate. The 4-D imaging strategy acquires a time series of images in B mode at several different locations along the heart, rendering out-of-phase image sequences. Then, our synchronization procedure uses similarity of local structures to find the phase shift between neighboring image sequences, employing M-mode images (extracted from the acquired B-mode images) to achieve computational efficiency. Furthermore, our procedure corrects the phase shifts by considering the phase lags introduced by peristaltic-like contractions of the embryonic heart wall. We applied the 4-D imaging strategy and synchronization procedure to reconstruct the cardiac outflow tract (OFT) of a chick embryo, imaged with OCT at early stages of development (Hamburger-Hamilton stage 18). We showed that the proposed synchronization procedure achieves efficiency without sacrificing accuracy and that the reconstructed 4-D images properly captured the dynamics of the OFT wall motion.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Aiping Liu, Ruikang K. Wang, Kent L. Thornburg, and Sandra Rugonyi "Efficient postacquisition synchronization of 4-D nongated cardiac images obtained from optical coherence tomography: application to 4-D reconstruction of the chick embryonic heart," Journal of Biomedical Optics 14(4), 044020 (1 July 2009). https://doi.org/10.1117/1.3184462

Published: 1 July 2009

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