Combined optical coherence tomography and electroretinography system for in vivo simultaneous morphological and functional imaging of the rodent retina

Alireza Akhlagh Moayed; Sepideh Hariri; Chulho Hyun; Bruce Doran; Timothy W. Kraft; Shelley Boyd; Kostadinka K. Bizheva

doi:10.1117/1.3475489

1 July 2010 Combined optical coherence tomography and electroretinography system for in vivo simultaneous morphological and functional imaging of the rodent retina

Alireza Akhlagh Moayed, Sepideh Hariri, Chulho Hyun, Bruce Doran, Timothy W. Kraft, Shelley Boyd, Kostadinka K. Bizheva

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Journal of Biomedical Optics, Vol. 15, Issue 4, 040506 (July 2010). https://doi.org/10.1117/1.3475489

Abstract

A combined ultrahigh resolution optical coherence tomography (UHROCT) and a electroretinography (ERG) system is presented for simultaneous imaging of the retinal structure and physiological response to light stimulation in the rodent eye. The 1060-nm UHROCT system provides ~3×5 µm (axial×lateral) resolution in the rat retina and time resolution of 22 µs. A custom-designed light stimulator integrated into the UHROCT imaging probe provides light stimuli with user-selected color, duration, and intensity. The performance of the combined system is demonstrated in vivo in healthy rats, and in a rat model of drug-induced outer retinal degeneration. Experimental results show correlation between the observed structural and physiological changes in the healthy and degenerated retina.

©(2010) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Alireza Akhlagh Moayed, Sepideh Hariri, Chulho Hyun, Bruce Doran, Timothy W. Kraft, Shelley Boyd, and Kostadinka K. Bizheva "Combined optical coherence tomography and electroretinography system for in vivo simultaneous morphological and functional imaging of the rodent retina," Journal of Biomedical Optics 15(4), 040506 (1 July 2010). https://doi.org/10.1117/1.3475489

Published: 1 July 2010

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