Toward soft-tissue elastography using digital holography to monitor surface acoustic waves

Shiguang Li; Karan D. Mohan; William W. Sanders; Amy L. Oldenburg

doi:10.1117/1.3646211

1 November 2011 Toward soft-tissue elastography using digital holography to monitor surface acoustic waves

Shiguang Li, Karan D. Mohan, William W. Sanders, Amy L. Oldenburg

Author Affiliations +

Journal of Biomedical Optics, Vol. 16, Issue 11, 116005 (November 2011). https://doi.org/10.1117/1.3646211

Abstract

Measuring the elasticity distribution inside the human body is of great interest because elastic abnormalities can serve as indicators of several diseases. We present a method for mapping elasticity inside soft tissues by imaging surface acoustic waves (SAWs) with digital holographic interferometry. With this method, we show that SAWs are consistent with Rayleigh waves, with velocities proportional to the square root of the elastic modulus greater than 2-40 kPa in homogeneous tissue phantoms. In two-layer phantoms, the SAW velocity transitions approximately from that of the lower layer to that of the upper layer as frequency is increased in agreement with the theoretical relationship between SAW dispersion and the depth-dependent stiffness profile. We also observed deformation in the propagation direction of SAWs above a stiff inclusion placed 8 mm below the surface. These findings demonstrate the potential for quantitative digital holography-based elastography of soft tissues as a noninvasive method for disease detection.

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Shiguang Li, Karan D. Mohan, William W. Sanders, and Amy L. Oldenburg "Toward soft-tissue elastography using digital holography to monitor surface acoustic waves," Journal of Biomedical Optics 16(11), 116005 (1 November 2011). https://doi.org/10.1117/1.3646211

Published: 1 November 2011

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KEYWORDS

Tissues

Digital holography

Elastography

Natural surfaces

Video

Wave propagation

Acoustics

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