Effect of tissue fluid on accurate determination of the complex refractive index of animal tissue

Jin Wang; Qing Ye; Zhi-Chao Deng; Wen-Yuan Zhou; Teng-Qian Sun; Chun-Ping Zhang; Jian-Guo Tian

doi:10.1117/1.JBO.17.7.075011

17 July 2012 Effect of tissue fluid on accurate determination of the complex refractive index of animal tissue

Jin Wang, Qing Ye, Zhi-Chao Deng, Wen-Yuan Zhou, Teng-Qian Sun, Chun-Ping Zhang, Jian-Guo Tian

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Journal of Biomedical Optics, Vol. 17, Issue 7, 075011 (July 2012). https://doi.org/10.1117/1.JBO.17.7.075011

Abstract

We investigate the effect of tissue fluid on the measurement of complex refractive index (RI) of animal tissue. A new model is proposed and verified through experimental results of simulation samples made of glycerol and methyl-red-doped poly(methyl methacrylate). Coupled with polarized optical reflectance measurements performed on several kinds of animal muscle tissues, RIs were resolved using the new model. We find that the tissue fluid existing at the prism-sample interface is unavoidable. We also find that with a change of proportion of the tissue fluid, the RI of muscle tissue can still be measured using the new model.

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Jin Wang, Qing Ye, Zhi-Chao Deng, Wen-Yuan Zhou, Teng-Qian Sun, Chun-Ping Zhang, and Jian-Guo Tian "Effect of tissue fluid on accurate determination of the complex refractive index of animal tissue," Journal of Biomedical Optics 17(7), 075011 (17 July 2012). https://doi.org/10.1117/1.JBO.17.7.075011

Published: 17 July 2012

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