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15 May 2012 Micro-structured polymer scaffolds fabricated by direct laser writing for tissue engineering
Paulius Danilevicius, Sima Rekštyte, Roaldas Gadonas, Mangirdas Malinauskas, Evaldas Balciunas, Rasa Jarasiene, Daiva Baltriukiene, Virginija Bukelskiene, Antanas Kraniauskas, Raimondas Sirmenis
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Journal of Biomedical Optics, Vol. 17, Issue 8, 081405 (May 2012). https://doi.org/10.1117/1.JBO.17.8.081405
Abstract
This work presents the latest results on direct laser writing of polymeric materials for tissue engineering applications. A femtosecond Yb:KGW laser (300 fs, 200 kHz, 515 nm) was used as a light source for non-linear lithography. Fabrication was implemented in various photosensitive polymeric materials, such as: hybrid organic-inorganic sol-gel based on silicon-zirconium oxides, commercial ORMOCER® class photoresins. These materials were structured via multi-photon polymerization technique with submicron resolution. Porous three-dimensional scaffolds for artificial tissue engineering were fabricated with constructed system and were up to several millimeters in overall size with 10 to 100 μm internal pores. Biocompatibility of the used materials was tested in primary rabbit muscle-derived stem cell culture in vitro and using laboratory rats in vivo. This interdisciplinary study suggests that proposed technique and materials are suitable for tissue engineering applications.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2012/$25.00 © 2012 SPIE
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Paulius Danilevicius, Sima Rekštyte, Roaldas Gadonas, Mangirdas Malinauskas, Evaldas Balciunas, Rasa Jarasiene, Daiva Baltriukiene, Virginija Bukelskiene, Antanas Kraniauskas, and Raimondas Sirmenis "Micro-structured polymer scaffolds fabricated by direct laser writing for tissue engineering," Journal of Biomedical Optics 17(8), 081405 (15 May 2012). https://doi.org/10.1117/1.JBO.17.8.081405
Published: 15 May 2012
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Cited by 76 scholarly publications and 1 patent.
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KEYWORDS
Polymers
Tissue engineering
In vitro testing
Tissues
Multiphoton lithography
Polymerization
Stem cells
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