Subcutaneous gold nanoroad detection with diffusion reflection measurement

Dror Fixler; Rinat Ankri

doi:10.1117/1.JBO.18.6.061226

6 February 2013 Subcutaneous gold nanoroad detection with diffusion reflection measurement

Dror Fixler, Rinat Ankri

Author Affiliations +

Journal of Biomedical Optics, Vol. 18, Issue 6, 061226 (February 2013). https://doi.org/10.1117/1.JBO.18.6.061226

Abstract

The ability to quantitatively and noninvasively detect nanoparticles nearby the skin surface has important implications on their development as an in vivo cancer diagnostic tool. The diffusion reflection (DR) method is a simple, noninvasive imaging technique which has been proven useful for the investigation of the optical parameters of the tissue. A new method is presented for the measurements of gold nanorod (GNR) concentration in tissue-like phantoms, based on DR measurement and intense light absorption of GNR. Monte Carlo simulations and tissue-like phantom measurements of the reflected light intensity are presented. The ability to extract optical properties of phantoms and their GNR concentrations from DR measurements is demonstrated, followed by a discussion about the best mathematical model for light propagation in tissues, based on the diffusion theory.

Fixler and Ankri: Subcutaneous gold nanorods detection with diffusion reflection measurement

Citation Download Citation

Dror Fixler and Rinat Ankri "Subcutaneous gold nanoroad detection with diffusion reflection measurement," Journal of Biomedical Optics 18(6), 061226 (6 February 2013). https://doi.org/10.1117/1.JBO.18.6.061226

Published: 6 February 2013

Access the abstract

JOURNAL ARTICLE
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

CITATIONS

Cited by 36 scholarly publications.

Explore citations on Lens.org

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Absorption

Scattering

Tissues

Tissue optics

Diffusion

Skin

Gold

Show All Keywords

RELATED CONTENT

Gold nanoparticles sensing with diffusion reflection measurement as a new...
Proceedings of SPIE (February 20 2014)

Spectral spatial classification combined with diffusion theory based inverse modeling...
Proceedings of SPIE (February 29 2016)

Diffuse reflectance imaging for non melanoma skin cancer detection using...
Proceedings of SPIE (April 27 2016)

Local diffuse reflectance from three-layered skin tissue structures
Proceedings of SPIE (August 18 1997)

Optical characterization of small biopsy samples
Proceedings of SPIE (October 08 2003)

Estimation of the optical properties of two layered tissue simulating...
Proceedings of SPIE (July 15 1999)

Effect of gold nanoparticles in the local heating of skin...
Proceedings of SPIE (June 02 2011)

Subscribe to Digital Library

Receive Erratum Email Alert

Show All Keywords

Keywords/Phrases

Search In:

Publication Years