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2 December 2014 Characteristics of laser-induced shock wave injury to the inner ear of rats
Takaomi Kurioka M.D., Takeshi Matsunobu, Katsuki Niwa, Atsushi Tamura, Satoko Kawauchi, Yasushi Satoh, Shunichi Sato, Akihiro Shiotani
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Journal of Biomedical Optics, Vol. 19, Issue 12, 125001 (December 2014). https://doi.org/10.1117/1.JBO.19.12.125001
Abstract
Recently, the number of blast injuries of the inner ear has increased in the general population. In blast-induced inner ear injury, a shock wave (SW) component in the blast wave is considered to play an important role in sensorineural hearing loss. However, the mechanisms by which an SW affects inner ear tissue remain largely unknown. We aimed to establish a new animal model for SW-induced inner ear injury by using laser-induced SWs (LISWs) on rats. The LISWs were generated by irradiating an elastic laser target with 694-nm nanosecond pulses of a ruby laser. After LISW application to the cochlea through bone conduction, auditory measurements revealed the presence of inner ear dysfunction, the extent of which depended on LISW overpressure. A significantly lower survival rate of hair cells and spiral ganglion neurons, as well as severe oxidative damage, were observed in the inner ear exposed to an LISW. Although considerable differences in the pressure characteristics exist between LISWs and SWs in real blast waves, the functional and morphological changes shown by the present LISW-based model were similar to those observed in real blast-induced injury. Thus, our animal model is expected to be useful for laboratory-based research of blast-induced inner ear injury.
© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2014/$25.00 © 2014 SPIE
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Takaomi Kurioka M.D., Takeshi Matsunobu, Katsuki Niwa, Atsushi Tamura, Satoko Kawauchi, Yasushi Satoh, Shunichi Sato, and Akihiro Shiotani "Characteristics of laser-induced shock wave injury to the inner ear of rats," Journal of Biomedical Optics 19(12), 125001 (2 December 2014). https://doi.org/10.1117/1.JBO.19.12.125001
Published: 2 December 2014
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Cited by 13 scholarly publications.
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KEYWORDS
Injuries
Ear
Animal model studies
Tissues
Bone
Luminescence
Microscopes
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