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24 July 2014 Structured light scatteroscopy
Venkataramanan Krishnaswamy, Jonathan T. Elliott, David M. McClatchy, Richard J. Barth M.D., Wendy A. Wells M.D., Brian W. Pogue, Keith D. Paulsen
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Journal of Biomedical Optics, Vol. 19, Issue 7, 070504 (July 2014). https://doi.org/10.1117/1.JBO.19.7.070504
Abstract
A new imaging approach, structured light scatteroscopy (SLS), is demonstrated, which offers rapid wide-field imaging of microscopic morphological variations in bulk tissue surfaces. Elastic scattering of light offers exquisite sensitivity to ultrastructural changes at multiple size scales ranging from nanometers to millimeters, but in bulk tissues the confounding effects of molecular absorption and strong multiple scattering of light often lead to a dramatic reduction in scatter contrast and specificity. It is demonstrated that the SLS using structured high spatial frequency illumination and detection to probe the tissue achieves direct, absorption-independent, high-resolution maps of the scattering response. The scattering response is observed to be dependent on both the wavelength and spatial frequency of choice, indicating a potential for multiscale probing of ultrastructural changes in superficial tissue layers. This methodology can be easily applied in most wide-field imaging systems.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Venkataramanan Krishnaswamy, Jonathan T. Elliott, David M. McClatchy, Richard J. Barth M.D., Wendy A. Wells M.D., Brian W. Pogue, and Keith D. Paulsen "Structured light scatteroscopy," Journal of Biomedical Optics 19(7), 070504 (24 July 2014). https://doi.org/10.1117/1.JBO.19.7.070504
Published: 24 July 2014
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Cited by 25 scholarly publications and 3 patents.
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KEYWORDS
Spatial frequencies
Laser sintering
Light scattering
Scattering
Tissues
Absorption
Reflectivity
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