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21 October 2015 All-plastic miniature fluorescence microscope for point-of-care readout of bead-based bioassays
Alessandra Forcucci, Michal Emanuel Pawlowski, Zachary Crannell, Ina Pavlova, Rebecca Richards-Kortum, Tomasz S. Tkaczyk
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Journal of Biomedical Optics, Vol. 20, Issue 10, 105010 (October 2015). https://doi.org/10.1117/1.JBO.20.10.105010
Abstract
A number of new platforms have been developed for multiplexed bioassays that rely on imaging targeted fluorescent beads labeled with different fluorescent dyes. We developed a compact, low-cost three-dimensional printed fluorescence microscope that can be used as a detector for mutiplexed, bead-based assays to support point-of-care applications. Images obtained with the microscope were analyzed to differentiate multiple analytes in a single sample with a comparable limit of detection to commercially available macroscopic assay platforms.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2015/$25.00 © 2015 SPIE
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Alessandra Forcucci, Michal Emanuel Pawlowski, Zachary Crannell, Ina Pavlova, Rebecca Richards-Kortum, and Tomasz S. Tkaczyk "All-plastic miniature fluorescence microscope for point-of-care readout of bead-based bioassays," Journal of Biomedical Optics 20(10), 105010 (21 October 2015). https://doi.org/10.1117/1.JBO.20.10.105010
Published: 21 October 2015
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Cited by 9 scholarly publications and 67 patents.
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KEYWORDS
Microscopes
Objectives
Luminescence
Point-of-care devices
Optical filters
Prototyping
Cameras
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