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21 August 2015 Auditory nerve impulses induced by 980 nm laser
Tian Guan, Kai Zhu, Jian Wang, Fei Chen, Yonghong He, Mocun Wu, Guohui Nie
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Journal of Biomedical Optics, Vol. 20, Issue 8, 088004 (August 2015). https://doi.org/10.1117/1.JBO.20.8.088004
Abstract
The discovery that a pulsed laser could trigger an auditory neural response inspired ongoing research on cochlear implants activated by optical stimulus rather than by electrical current. However, most studies to date have used visible light (532 nm) or long-wavelength near-infrared (<1840  nm) and involved making a hole in the cochlea. This paper investigates the effect of optical parameters on the optically evoked compound action potentials (oCAPs) from the guinea pig cochlea, using a pulsed semiconductor near-infrared laser (980 nm) without making a hole in the cochlea. Synchronous trigger laser pulses were used to stimulate the cochlea, before and after deafening, upon varying the pulse duration (30–1000  μs) and an amount of radiant energy (0–53.2  mJ/cm2). oCAPs were successfully recorded after deafening. The amplitude of the oCAPs increased as the infrared radiant energy was increased at a fixed 50  μs pulse duration, and decreased with a longer pulse duration at a fixed 37.1  mJ/cm2 radiant energy. The latency of the oCAPs shortened with increasing radiant energy at a fixed pulse duration. With a higher stimulation rate, the amplitude of the oCAPs’ amplitude decreased.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Tian Guan, Kai Zhu, Jian Wang, Fei Chen, Yonghong He, Mocun Wu, and Guohui Nie "Auditory nerve impulses induced by 980 nm laser," Journal of Biomedical Optics 20(8), 088004 (21 August 2015). https://doi.org/10.1117/1.JBO.20.8.088004
Published: 21 August 2015
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Cited by 15 scholarly publications.
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KEYWORDS
Pulsed laser operation
Nerve
Action potentials
Electrodes
Laser tissue interaction
Laser scattering
Optical fibers
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