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23 February 2017 Dry coupling for whole-body small-animal photoacoustic computed tomography
Chenghung Yeh, Lei Li, Liren Zhu, Jun Xia, Chiye Li, Wanyi Chen, Alejandro Garcia-Uribe, Konstantin I. Maslov, Lihong V. Wang
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Journal of Biomedical Optics, Vol. 22, Issue 4, 041017 (February 2017). https://doi.org/10.1117/1.JBO.22.4.041017
Abstract
We have enhanced photoacoustic computed tomography with dry acoustic coupling that eliminates water immersion anxiety and wrinkling of the animal and facilitates incorporating complementary modalities and procedures. The dry acoustic coupler is made of a tubular elastic membrane enclosed by a closed transparent water tank. The tubular membrane ensures water-free contact with the animal, and the closed water tank allows pressurization for animal stabilization. The dry coupler was tested using a whole-body small-animal ring-shaped photoacoustic computed tomography system. Dry coupling was found to provide image quality comparable to that of conventional water coupling.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2017/$25.00 © 2017 SPIE
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Chenghung Yeh, Lei Li, Liren Zhu, Jun Xia, Chiye Li, Wanyi Chen, Alejandro Garcia-Uribe, Konstantin I. Maslov, and Lihong V. Wang "Dry coupling for whole-body small-animal photoacoustic computed tomography," Journal of Biomedical Optics 22(4), 041017 (23 February 2017). https://doi.org/10.1117/1.JBO.22.4.041017
Received: 10 August 2016; Accepted: 8 February 2017; Published: 23 February 2017
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Cited by 17 scholarly publications.
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KEYWORDS
Photoacoustic tomography
Kidney
Photoacoustic spectroscopy
Acquisition tracking and pointing
Image quality
In vivo imaging
Lithium
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