Estimation of cerebral metabolic rate of oxygen consumption using combined multiwavelength photoacoustic microscopy and Doppler microultrasound

Yan Jiang; Roger Zemp

doi:10.1117/1.JBO.23.1.016009

18 January 2018 Estimation of cerebral metabolic rate of oxygen consumption using combined multiwavelength photoacoustic microscopy and Doppler microultrasound

Yan Jiang, Roger Zemp

Author Affiliations +

Journal of Biomedical Optics, Vol. 23, Issue 1, 016009 (January 2018). https://doi.org/10.1117/1.JBO.23.1.016009

Abstract

The metabolic rate of oxygen consumption is an important metric of tissue oxygen metabolism and is especially critical in the brain, yet few methods are available for measuring it. We use a custom combined photoacoustic-microultrasound system and demonstrate cerebral oxygen consumption estimation in vivo. In particular, the cerebral metabolic rate of oxygen consumption was estimated in a murine model during variation of inhaled oxygen from hypoxia to hyperoxia. The hypothesis of brain autoregulation was confirmed with our method even though oxygen saturation and flow in vessels changed.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Yan Jiang and Roger Zemp "Estimation of cerebral metabolic rate of oxygen consumption using combined multiwavelength photoacoustic microscopy and Doppler microultrasound," Journal of Biomedical Optics 23(1), 016009 (18 January 2018). https://doi.org/10.1117/1.JBO.23.1.016009

Received: 13 June 2017; Accepted: 16 November 2017; Published: 18 January 2018

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