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30 January 2019 Automated phase unwrapping in Doppler optical coherence tomography
Shaohua Pi, Acner Camino, Xiang Wei, Tristan T. Hormel, William Cepurna, John C. Morrison, Yali Jia
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Journal of Biomedical Optics, Vol. 24, Issue 1, 010502 (January 2019). https://doi.org/10.1117/1.JBO.24.1.010502
Abstract
Phase wrapping is a crucial issue in Doppler optical coherence tomography (OCT) and restricts its automatic implementation for clinical applications that quantify total retinal blood flow. We propose an automated phase-unwrapping technique that takes advantage of the parabolic profile of blood flow velocity in vessels. Instead of inspecting the phase shift manually, the algorithm calculates the gradient magnitude of the phase shift on the cross-sectional image and automatically detects the presence of phase wrapping. The voxels affected by phase wrapping are corrected according to the determined flow direction adjacent to the vessel walls. We validated this technique in the rodent retina using a prototype visible-light OCT and in the human retina with a commercial infrared OCT system. We believe this signal processing method may well accelerate clinical applications of Doppler OCT in ophthalmology.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Shaohua Pi, Acner Camino, Xiang Wei, Tristan T. Hormel, William Cepurna, John C. Morrison, and Yali Jia "Automated phase unwrapping in Doppler optical coherence tomography," Journal of Biomedical Optics 24(1), 010502 (30 January 2019). https://doi.org/10.1117/1.JBO.24.1.010502
Received: 7 December 2018; Accepted: 21 January 2019; Published: 30 January 2019
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Cited by 4 scholarly publications and 1 patent.
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KEYWORDS
Optical coherence tomography
Doppler effect
Blood circulation
Doppler tomography
Phase shifts
Veins
Retina
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