Methodology for examining polarized light interactions with tissues and tissue-like media in the exact backscattering direction

Ryan C. N. Studinski; I. Alex Vitkin

doi:10.1117/1.430004

1 July 2000 Methodology for examining polarized light interactions with tissues and tissue-like media in the exact backscattering direction

Ryan C. N. Studinski, I. Alex Vitkin

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Journal of Biomedical Optics, Vol. 5, Issue 3, (July 2000). https://doi.org/10.1117/1.430004

The properties of polarized light emerging from turbid media in the exact backscattering direction are studied by modulating the incident light polarization state and isolating the synchronous signal with lock-in amplifier detection. The results are reported for polystyrene microsphere suspensions in distilled water, with and without glucose, and for both ex vivo and in vivo biological tissues. A new theoretical formulation based on Mueller calculus is developed to describe the observed behavior of the backscattered light in terms of two sample parameters: optical rotation and depolarization. This technique proved successful in modeling both phantom and tissue samples. Results showed the presence of a significant surviving polarization fraction in the backscattering direction even in extremely dense optical phantom media, an important finding that has not been observed at other detection angles. Substantial polarized light preservation in biological tissue samples is also demonstrated for this detection geometry. This illustrates the potential of using polarized light to investigate turbid biological materials in vivo in retroreflection geometry.

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Ryan C. N. Studinski and I. Alex Vitkin "Methodology for examining polarized light interactions with tissues and tissue-like media in the exact backscattering direction," Journal of Biomedical Optics 5(3), (1 July 2000). https://doi.org/10.1117/1.430004

Published: 1 July 2000

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KEYWORDS

Polarization

Tissues

Backscatter

Light scattering

Scattering

Tissue optics

Glucose

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