New method for evaluation of in vivo scattering and refractive index properties obtained with optical coherence tomography

Alexander R. Knuettel; Slavtcho M. Bonev; W. Knaak

doi:10.1117/1.1647544

1 March 2004 New method for evaluation of in vivo scattering and refractive index properties obtained with optical coherence tomography

Alexander R. Knuettel, Slavtcho M. Bonev, W. Knaak

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Journal of Biomedical Optics, Vol. 9, Issue 2, (March 2004). https://doi.org/10.1117/1.1647544

Optical coherence tomography (OCT) provides more parameters than pure morphology does. In a recent paper [A. Knuettel and M. Boehlau-Godau, J. Biomed. Opt. 5(1) 83–92 (2000)] we have shown that the refractive index (RI) can be evaluated in a localized manner in skin tissue under in vivo conditions. Based on a theory, originally developed for light detecting and ranging applications [L. Thrane et al., J. Opt. Soc. Am. A 17(3) 484–490 (2000)], the parameter mean scattering angle (MSA) could be derived in addition to RI. The effects of hydration on MSA and RI have been evaluated in vitro in pigskin and in vivo in human skin with our OCT scanner SkinDex 300®. These parameters may have a viable impact in (cosmetic) skin research and clinical diagnoses. To the best of our knowledge, this is the first time that (multiple) scattering of light has been quantified through the observation of a new scattering parameter under in vivo conditions.

©(2004) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Alexander R. Knuettel, Slavtcho M. Bonev, and W. Knaak "New method for evaluation of in vivo scattering and refractive index properties obtained with optical coherence tomography," Journal of Biomedical Optics 9(2), (1 March 2004). https://doi.org/10.1117/1.1647544

Published: 1 March 2004

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KEYWORDS

Scattering

Skin

Optical coherence tomography

In vivo imaging

Signal detection

Light scattering

Multiple scattering

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