Glaucoma progression detection using nonlocal Markov random field prior

Akram Belghith; Christopher Bowd; Felipe A. Medeiros; Madhusudhanan Balasubramanian; Robert N. Weinreb; Linda M. Zangwill

doi:10.1117/1.JMI.1.3.034504

29 December 2014 Glaucoma progression detection using nonlocal Markov random field prior

Akram Belghith, Christopher Bowd, Felipe A. Medeiros, Madhusudhanan Balasubramanian, Robert N. Weinreb, Linda M. Zangwill

Author Affiliations +

Journal of Medical Imaging, Vol. 1, Issue 3, 034504 (December 2014). https://doi.org/10.1117/1.JMI.1.3.034504

Abstract

Glaucoma is neurodegenerative disease characterized by distinctive changes in the optic nerve head and visual field. Without treatment, glaucoma can lead to permanent blindness. Therefore, monitoring glaucoma progression is important to detect uncontrolled disease and the possible need for therapy advancement. In this context, three-dimensional (3-D) spectral domain optical coherence tomography (SD-OCT) has been commonly used in the diagnosis and management of glaucoma patients. We present a new framework for detection of glaucoma progression using 3-D SD-OCT images. In contrast to previous works that use the retinal nerve fiber layer thickness measurement provided by commercially available instruments, we consider the whole 3-D volume for change detection. To account for the spatial voxel dependency, we propose the use of the Markov random field (MRF) model as a prior for the change detection map. In order to improve the robustness of the proposed approach, a nonlocal strategy was adopted to define the MRF energy function. To accommodate the presence of false-positive detection, we used a fuzzy logic approach to classify a 3-D SD-OCT image into a “non-progressing” or “progressing” glaucoma class. We compared the diagnostic performance of the proposed framework to the existing methods of progression detection.

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Akram Belghith, Christopher Bowd, Felipe A. Medeiros, Madhusudhanan Balasubramanian, Robert N. Weinreb, and Linda M. Zangwill "Glaucoma progression detection using nonlocal Markov random field prior," Journal of Medical Imaging 1(3), 034504 (29 December 2014). https://doi.org/10.1117/1.JMI.1.3.034504

Published: 29 December 2014

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