Translator Disclaimer
20 November 2019 Stochastic tissue window normalization of deep learning on computed tomography
Author Affiliations +

Tissue window filtering has been widely used in deep learning for computed tomography (CT) image analyses to improve training performance (e.g., soft tissue windows for abdominal CT). However, the effectiveness of tissue window normalization is questionable since the generalizability of the trained model might be further harmed, especially when such models are applied to new cohorts with different CT reconstruction kernels, contrast mechanisms, dynamic variations in the acquisition, and physiological changes. We evaluate the effectiveness of both with and without using soft tissue window normalization on multisite CT cohorts. Moreover, we propose a stochastic tissue window normalization (SWN) method to improve the generalizability of tissue window normalization. Different from the random sampling, the SWN method centers the randomization around the soft tissue window to maintain the specificity for abdominal organs. To evaluate the performance of different strategies, 80 training and 453 validation and testing scans from six datasets are employed to perform multiorgan segmentation using standard 2D U-Net. The six datasets cover the scenarios, where the training and testing scans are from (1) same scanner and same population, (2) same CT contrast but different pathology, and (3) different CT contrast and pathology. The traditional soft tissue window and nonwindowed approaches achieved better performance on (1). The proposed SWN achieved general superior performance on (2) and (3) with statistical analyses, which offers better generalizability for a trained model.

© 2019 Society of Photo-Optical Instrumentation Engineers (SPIE) 2329-4302/2019/$28.00 © 2019 SPIE
Yuankai Huo, Yucheng Tang, Yunqiang Chen, Dashan Gao, Shizhong Han, Shunxing Bao, Smita De, James G. Terry, Jeffrey J. Carr, Richard G. Abramson, and Bennett A. Landman "Stochastic tissue window normalization of deep learning on computed tomography," Journal of Medical Imaging 6(4), 044005 (20 November 2019).
Received: 24 April 2019; Accepted: 4 November 2019; Published: 20 November 2019

Back to Top