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30 September 2016 Visualizing and mapping the cerebellum with serial optical coherence scanner
Chao J. Liu, Kristen E. Williams, Harry T. Orr, Taner Akkin
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Neurophotonics, Vol. 4, Issue 1, 011006 (September 2016). https://doi.org/10.1117/1.NPh.4.1.011006
Abstract
We present the visualization of the mouse cerebellum and adjacent brainstem using a serial optical coherence scanner, which integrates a vibratome slicer and polarization-sensitive optical coherence tomography for ex vivo imaging. The scanner provides intrinsic optical contrasts to distinguish the cerebellar cortical layers and white matter. Images from serial scans reveal the large-scale anatomy in detail and map the nerve fiber pathways in the cerebellum and brainstem. By incorporating a water-immersion microscope objective, we also present high-resolution tiled images that delineate fine structures in the cerebellum and brainstem.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE) 2329-423X/2016/$25.00 © 2016 SPIE
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Chao J. Liu, Kristen E. Williams, Harry T. Orr, and Taner Akkin "Visualizing and mapping the cerebellum with serial optical coherence scanner," Neurophotonics 4(1), 011006 (30 September 2016). https://doi.org/10.1117/1.NPh.4.1.011006
Published: 30 September 2016
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Cited by 14 scholarly publications.
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KEYWORDS
Cerebellum
Reflectivity
Visualization
Brain
Nerve
Scanners
Brain mapping
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