Gas analysis of human exhalation by tunable diode laser spectroscopy

Eugene V. Stepanov; Konstantin L. Moskalenko

doi:10.1117/12.60690

1 February 1993 Gas analysis of human exhalation by tunable diode laser spectroscopy

Eugene V. Stepanov, Konstantin L. Moskalenko

Author Affiliations +

Optical Engineering, Vol. 32, Issue 2, (February 1993). https://doi.org/10.1117/12.60690

Abstract

Results of the application of a tunable diode laser (TDL) to determining the trace gas components of human exhalation are presented. The analyzer is specially developed to measure both carbonoxides (CO and C0₂) in expired air. A few results illuminating possible applications of TDLs in high-sensitivity medical diagnostics have been obtained. For nonsmokers, expired concentrations of CO are slightly higher than those in inhaled air. The specific surplus value seems to be independent of the ambient atmospheric CO content. The surplus CO content increases by more than an order of magnitude just after intensive exercises, e.g., jogging. For smokers, the pharmacokinetic of abundant CO removal from the organism could be investigated by this technique, which provides quick and reliable measurements of smoking status. Breath-holding synchronous measurements of CO and CO₂ in exhalation demonstrate behavior that is different with breath-holding time. The method seems useful for the investigation of phenomena such as molecular pulmonary diffusion through the alveolar-capillary membrane and an organism's adaptation to oxygen shortage. Prospects for the development and application of diode laser spectroscopy to trace gas analysis in medicine are also discussed.

Citation Download Citation

Eugene V. Stepanov and Konstantin L. Moskalenko "Gas analysis of human exhalation by tunable diode laser spectroscopy," Optical Engineering 32(2), (1 February 1993). https://doi.org/10.1117/12.60690

Published: 1 February 1993

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available