Jabodetabek and Greater Bandung areas experiencing the phenomenon of urban expansion which has caused both metropolitan areas to be more connected and become a mega-urban area by a corridor through a conurbation process. Karawang regency is part of the region in the Jakarta-Bandung mega-urban corridor. Vegetated lands in Karawang Regency are threatened by land conversion as a result of the Jakarta-Bandung conurbation process which tends to trigger the formation of the Jakarta-Bandung Mega-Urban Region. The increasing population in Karawang Regency has increasingly triggered the conversion of vegetated lands into built-up lands so that it can cause the region to be prone to anthropogenic disasters such as flood because of water catchment areas that reduced. The aims of this study are to analyze the land cover changes that occured in Karawang Regency in 2005–2015 and 2015–2025 and mapping the floodprone areas in Karawang Regency. Land cover changes analysis is carried out by overlapping Landsat Imagery of land cover in the 2005 and 2015 and 2015 and 2025 based on projection results using CA-Markov method. Mapping the floodprone areas is carried out by a Weighted Overlay process on variables or factors that are considered influential on the occurrence of floods. Karawang Regency has experienced an increase in land use change, especially changes in vegetated lands to built-up lands from year to year. Flood-prone areas analysis result in Karawang Regency show that most of the total area of Karawang Regency is classified as high and moderate classification flood-prone areas.