Dr. Anjul Khadria Profile

Dr. Anjul Khadria

at Caltech

SPIE Involvement:

Author

Publications (3)

Proceedings Article | 13 March 2024 Presentation

Ultrafast single-shot 3D photoacoustic tomography in vivo using a single-element detector

Yide Zhang, Peng Hu, Lei Li, Rui Cao, Anjul Khadria, Konstantin Maslov, Xin Tong, Yushun Zeng, Laiming Jiang, Qifa Zhou, Lihong Wang

Proceedings Volume PC12842, PC128420I (2024) https://doi.org/10.1117/12.3007503

KEYWORDS: Ultrafast imaging, Hemodynamics, Photoacoustic tomography, In vivo imaging, Imaging systems, Ultrafast phenomena, Stereoscopy, Point-of-care devices, Calibration, CT reconstruction

Read Abstract +

SPIE Journal Paper | 30 November 2023 Open Access

Photoacoustic imaging of the dynamics of a dye-labeled IgG4 monoclonal antibody in subcutaneous tissue reveals a transient decrease in murine blood oxygenation under anesthesia

Anjul Khadria, Chad Paavola, Konstantin Maslov, Patricia Brown-Augsburger, Patrick F. Grealish, Emmanuel Lozano, Rui Cao, Junhui Shi, John Beals, Sunday Oladipupo, Lihong Wang

JBO, Vol. 28, Issue 11, 116002, (November 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.11.116002

KEYWORDS: Antibodies, Ear, Blood, Dyes, Photoacoustic imaging, Monoclonal antibodies, Photoacoustic spectroscopy, Tissues, Oxygen, Absorption

Read Abstract +

SignificanceOver 100 monoclonal antibodies have been approved by the U.S. Food and Drug Administration (FDA) for clinical use; however, a paucity of knowledge exists regarding the injection site behavior of these formulated therapeutics, particularly the effect of antibody, formulation, and tissue at the injection site. A deeper understanding of antibody behavior at the injection site, especially on blood oxygenation through imaging, will help design improved versions of the therapeutics for a wide range of diseases.AimThe aim of this research is to understand the dynamics of monoclonal antibodies at the injection site as well as how the antibody itself affects the functional characteristics of the injection site [e.g., blood oxygen saturation (sO2)].ApproachWe employed triple-wavelength equipped functional photoacoustic imaging to study the dynamics of dye-labeled and unlabeled monoclonal antibodies at the site of injection in a mouse ear. We injected a near-infrared dye-labeled (and unlabeled) human IgG4 isotype control antibody into the subcutaneous space in mouse ears to analyze the injection site dynamics and quantify molecular movement, as well as its effect on local hemodynamics.ResultsWe performed pharmacokinetic studies of the antibody in different regions of the mouse body to show that dye labeling does not alter the pharmacokinetic characteristics of the antibody and that mouse ear is a viable model for these initial studies. We explored the movement of the antibody in the interstitial space to show that the bolus area grows by ∼300 % over 24 h. We discovered that injection of the antibody transiently reduces the local sO2 levels in mice after prolonged anesthesia without affecting the total hemoglobin content and oxygen extraction fraction.ConclusionsThis finding on local oxygen saturation opens a new avenue of study on the functional effects of monoclonal antibody injections. We also show the suitability of the mouse ear model to study antibody dynamics through high-resolution imaging techniques. We quantified the movement of antibodies at the injection site caused by the interstitial fluid, which could be helpful for designing antibodies with tailored absorption speeds in the future.

DOWNLOAD PAPER

Proceedings Article | 9 March 2023 Presentation

Photoacoustic vector tomography for deep hemodynamic imaging

Yang Zhang, Joshua Olick-Gibson, Anjul Khadria, Lihong Wang

Proceedings Volume PC12379, PC123790K (2023) https://doi.org/10.1117/12.2655420

KEYWORDS: Photoacoustic spectroscopy, Hemodynamics, Tomography, Photoacoustic tomography, Optical imaging, Diffusion, Blood circulation, Blood, Blood vessels, Visualization

Read Abstract +

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Keywords/Phrases

Search In:

Publication Years