Mr. Aamr M. Hasanjee Profile

Aamr M. Hasanjee

at Univ of Central Oklahoma

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Author

Publications (10)

Proceedings Article | 23 February 2017 Paper

The effects of single-walled carbon nanotubes on cancer cell migration using a pancreatic tumor model

Elivia Layton, Rachel McNamar, Aamr Hasanjee, Cayman McNair, Brianna Stevens, Melville Vaughan, Feifan Zhou, Wei Chen

Proceedings Volume 10065, 100650Z (2017) https://doi.org/10.1117/12.2253471

KEYWORDS: Cancer, Single walled carbon nanotubes, Collagen, Matrices, Oncology, In vivo imaging, Microscopes, Optical simulations, Cell death, Photodynamic therapy, Pancreatic cancer, Tumors, 3D modeling, Tumor growth modeling, Laser irradiation, Distance measurement

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Proceedings Article | 23 February 2017 Paper

Comparing the photothermal effects of gold nanorods and single-walled carbon nanotubes in cancer models

Connor West, Aamr Hasanjee, Blake Young, Roman Wolf, Kegan Silk, Rianna Ingalls, Feifan Zhou, Wei Chen

Proceedings Volume 10065, 100650R (2017) https://doi.org/10.1117/12.2250704

KEYWORDS: Nanorods, Single walled carbon nanotubes, Cancer, Photothermal effect, Oncology, Nanoparticles, Gold, Laser irradiation, Carbon nanotubes, Phototherapy, Laser energy, Nanomaterials, Tumor growth modeling

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Laser Immunotherapy (LIT) is an innovative cancer treatment modality that is specifically targeted towards treating late-stage, metastatic cancer. This treatment modality utilizes laser irradiation in combination with active immune system stimulation to induce a systemic anti-tumor immune response against metastatic cancer. Nanoparticles have recently been utilized to support and increase the photothermal effect of the laser irradiation by absorbing the light energy produced from the laser and converting that energy into thermal energy. In the past, single-walled carbon nanotubes (SWNTs) have been the main choice in nanotechnology, however, recent studies have shown that gold nanorods (AuNRs) are a prospective alternative that may produce photothermal effects similar to SWNTs. Due to the precedence of gold biomaterials currently having approval for use in various treatments for humans, AuNRs are regarded to be a safer option than SWNTs. The goal of this study is to precisely compare any differences in photothermal effects between AuNRs and SWNTs. Both types of nanoparticles were irradiated with the same wavelength of near-infrared light to ascertain the photothermal effects in gel phantom tumor models, aqueous solutions, and metastatic cancer cell cultures. We discerned from the results that the AuNRs could be equally or more effective than SWNTs in absorbing the light energy from the laser and converting it into thermal energy. In both solution and gel studies, AuNRs were shown to be more efficient than SWNTs in creating thermal energy, while in cell studies, no definitive differences between AuNRs and SWNTs were observed. The cytotoxicity of both nanoparticles needs further assessment in future studies. Given these results, AuNRs are comparable to SWNTs, even superior in certain aspects. This advances the opportunity to use AuNRs as replacements for SWNTs in LIT treatments. The results from this study will contribute to any subsequent studies in the development of this cancer modality using photothermal therapy enhanced by nanoparticles.

Proceedings Article | 27 April 2016 Presentation

Development of InCVAX as a novel in situ autologous vaccine for metastatic cancers (Conference Presentation)

Tomas Hode, Luciano Alleruzzo, Joseph Raker, Samuel Siu Kit Lam, Robert Nordquist, Wei Chen

Proceedings Volume 9709, 97090I (2016) https://doi.org/10.1117/12.2216110

KEYWORDS: Cancer, Oncology, Clinical trials, Phototherapy, Clinical research, Breast cancer, Biomedical optics, Current controlled current source

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Proceedings Article | 21 March 2016 Presentation + Paper

Comparison of the photothermal effects of 808nm gold nanorod and indocyanine green solutions using an 805nm diode laser

Aamr Hasanjee, Feifan Zhou, Connor West, Kegan Silk, Austin Doughty, Cody Bahavar, Wei Chen

Proceedings Volume 9709, 97090A (2016) https://doi.org/10.1117/12.2214631

KEYWORDS: Gold, Indocyanine green, Semiconductor lasers, Laser irradiation, Photothermal effect, Cancer, Absorption, Single walled carbon nanotubes, Nanorods, Tumors

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Proceedings Article | 10 March 2016 Paper

The effects of laser immunotherapy on cancer cell migration

Cody Bahavar, Feifan Zhou, Aamr Hasanjee, Elivia Layton, Anh Lam, Wei Chen, Melville Vaughan

Proceedings Volume 9709, 97090X (2016) https://doi.org/10.1117/12.2216592

KEYWORDS: Laser irradiation, Cancer, Single walled carbon nanotubes, In vitro testing, Resistance, Optical properties, In vivo imaging, Tumors, Biomedical optics, Medical research, Biology

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Proceedings Article | 9 March 2016 Paper

Temperature distribution in target tumor tissue and photothermal tissue destruction during laser immunotherapy

Austin Doughty, Aamr Hasanjee, Alex Pettitt, Kegan Silk, Hong Liu, Wei Chen, Feifan Zhou

Proceedings Volume 9709, 97090N (2016) https://doi.org/10.1117/12.2209692

KEYWORDS: Cancer, Laser tissue interaction, Laser irradiation, Oncology, Laser therapeutics, Temperature metrology, Molecules, Proteins, Tissues, Photothermal effect, Tumors, Infrared cameras, Thermography, Infrared imaging, Cameras

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Proceedings Article | 9 March 2015 Paper

Photo-nano immunotherapy for metastatic breast cancer using synergistic single-walled carbon nanotubes and glycated chitosan

Feifan Zhou, Aamr Hasanjee, Austin Doughty, Connor West, Hong Liu, Wei Chen

Proceedings Volume 9324, 93240L (2015) https://doi.org/10.1117/12.2079378

KEYWORDS: Tumors, Single walled carbon nanotubes, Breast cancer, Laser therapeutics, Laser irradiation, Cancer, In vivo imaging, Biomedical optics, Oncology, Photothermal effect

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Proceedings Article | 9 March 2015 Paper

The immunological response created by interstitial and non-invasive laser immunotherapy

Cody Bahavar, Feifan Zhou, Aamr Hasanjee, Connor West, Robert Nordquist, Tomas Hode, Hong Liu, Wei Chen

Proceedings Volume 9324, 93240D (2015) https://doi.org/10.1117/12.2082658

KEYWORDS: Tumors, Laser irradiation, Single walled carbon nanotubes, Cancer, Skin, Biomedical optics, Clinical trials, Breast cancer, Melanoma, Carbon nanotubes

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Laser immunotherapy (LIT) is an innovative cancer modality that uses laser irradiation and immunological stimulation to treat late-stage, metastatic cancers. LIT can be performed through either interstitial or non-invasive laser irradiation. Although LIT is still in development, recent clinical trials have shown that it can be used to successfully treat patients with late-stage breast cancer and melanoma. The development of LIT has been focused on creating an optimal immune response created by irradiating the tumor. One important factor that could enhance the immune response is the duration of laser irradiation. Irradiating the tumor for a shorter or longer amount of time could weaken the immune response created by LIT. Another factor that could weaken this immune response is the proliferation of regulatory T cells (TRegs) in response to the laser irradiation. However, low dose cyclophosphamide (CY) can help suppress the proliferation of TRegs and help create a more optimal immune response. An additional factor that could weaken the effectiveness of LIT is the selectivity of the laser. If LIT is performed non-invasively, then deeply embedded tumors and highly pigmented skin could cause an uneven temperature distribution inside the tumor. To solve this problem, an immunologically modified carbon nanotube system was created by using an immunoadjuvant known as glycated chitosan (GC) as a surfactant for single-walled carbon nanotubes (SWNTs) to immunologically modify SWNTs. SWNT-GC retains the optical properties of SWNTs and the immunological functions of GC to help increase the selectivity of the laser and create a more optimal immune response. In this preliminary study, tumor-bearing rats were treated with LIT either interstitially by an 805-nm laser with GC and low-dose CY, or non-invasively by a 980-nm laser with SWNT-GC. The goal was to observe the effects of CY on the immune response induced by LIT and to also determine the effect of irradiation duration for interstitial and noninvasive LIT.

Proceedings Article | 9 March 2015 Paper

Anti-tumor response induced by immunologically modified carbon nanotubes and laser irradiation using rat mammary tumor model

Joseph Acquaviva, Aamr Hasanjee, Cody Bahavar, Fefian Zhou, Hong Liu, Eric Howard, Liz Bullen, Ricardo Silvy, Wei Chen

Proceedings Volume 9324, 932415 (2015) https://doi.org/10.1117/12.2080890

KEYWORDS: Tumors, Single walled carbon nanotubes, Laser irradiation, Cancer, Carbon nanotubes, Cell death, Oncology, Magnesium, Biomedical optics, Nanotechnology

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Proceedings Article | 27 February 2014 Paper

Effects of laser immunotherapy on tumor microenvironment

Joseph Acquaviva, Ethan Wood, Aamr Hasanjee, Wei Chen, Melville Vaughan

Proceedings Volume 8944, 894407 (2014) https://doi.org/10.1117/12.2040680

KEYWORDS: Collagen, Tumors, Laser irradiation, Cancer, Biomedical optics, Breast cancer, Microscopes, Phototherapy, Oncology, Digital imaging

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Showing 5 of 10 publications

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