Dr. Abby Wilson Profile

Dr. Abby Wilson

at Univ of Cambridge

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Publications (2)

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Proceedings Article | 9 March 2020 Presentation

Development of a compact multimodal imaging system for rapid characterisation of intrinsic optical properties of freshly excised tissue (Conference Presentation)

Jonghee Yoon, Abby Wilson, Dale Waterhouse, Travis Sawyer, Massimiliano di Pietro, Rebecca Fitzgerald, Sarah Bohndiek

Proceedings Volume 11232, 112320H (2020) https://doi.org/10.1117/12.2545199

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Advanced optical endoscopic imaging techniques, including hyperspectral and holographic endoscopy, have shown promise in the improved diagnosis of the early stage of cancer. However, clinical applications of these imaging systems are still limited due to unclear diagnostic optical properties. Here, we developed a compact multimodal imaging system that enables hyperspectral imaging, spatial-frequency domain imaging, and 3D profilometric imaging to characterise the optimal optical features for the early detection of lesions. Optical properties of fresh specimens obtained from patients were measured within 30 minutes, and then histopathological assessment of specimens was performed to link extracted optical features to gold-standard diagnosis. With further sample collection and system refinements, this system can be used for high-throughput optical characterisation of fresh tissue specimens, allowing us to determine the optical signatures of early-stage disease.

Proceedings Article | 13 March 2019 Presentation

A speckle interferometric technique for the evaluation of corneal biomechanics under physiological pressure variations (Conference Presentation)

Abby Wilson, John Marshall

Proceedings Volume 10880, 108800Z (2019) https://doi.org/10.1117/12.2507660

KEYWORDS: Speckle, Interferometry, Cornea, Associative arrays, Surgery, Time metrology, Eye

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Clinical assessment of corneal biomechanics currently relies on evaluation of the response of a cornea to an air-puff directed at its centre. Despite this method showing potential for identifying the presence of biomechanical abnormalities, it cannot be used to quantify corneal biomechanical properties and it provides limited spatial information. There is currently widespread interest in the development of techniques capable of spatially mapping corneal biomechanics, as access to this information could not only accelerate the diagnosis and enhance the treatment of keratoconus, through enabling customised and individualised treatment protocols; it could also permit technologies such as corneal crosslinking to be optimised to offer a minimally-invasive alternative to refractive surgery, lowering the risk of complications, such as corneal ectasia, associated with current procedures. Here we present a method, using speckle interferometric techniques, to measure the full-field displacement of the cornea in response to intra-ocular pressure changes equivalent to those that occur during the cardiac cycle, over a measurement time of several milliseconds. To demonstrate its effectiveness for biomechanical assessment, ex vivo measurements were performed for 40 porcine corneas and 6 human corneas before and after crosslinking in isolated topographic regions. Prior to crosslinking, all corneas demonstrated significant regional variability in response to loading. Regional reductions in displacement of between 16 % to 80 % were observed after crosslinking dependent upon treatment location. These initial data demonstrate both the necessity for full-field evaluation of biomechanics and the potential for crosslinking to be used to alter the refractive power of the eye.

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