Prof. Adam Q. Bauer Profile

Prof. Adam Q. Bauer

at Washington Univ. School of Medicine in St. Louis

SPIE Involvement:

Author

Publications (19)

Proceedings Article | 17 March 2023 Presentation

Mapping local and global interactions between parvalbumin inhibitory neurons and excitatory neurons over the cortex in awake mice

Xiaodan Wang, Annie Bice, Adam Bauer

Proceedings Volume PC12366, PC1236605 (2023) https://doi.org/10.1117/12.2650521

KEYWORDS: Neurons, Brain mapping, Visualization, Optogenetics, Imaging systems, Calcium, Somatosensory cortex, Photovoltaics, Photostimulation, Luminescence

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Proceedings Article | 17 March 2023 Presentation

Light-based motor mapping of multiple limbs using deep learning reveals behaviorally relevant cortical motor representations

Nischal Khanal, Jonah Padawer-Curry, Kevin Schulte, Trevor Voss, Byungchan Kim, Annie Bice, Adam Bauer

Proceedings Volume PC12366, PC1236604 (2023) https://doi.org/10.1117/12.2649138

KEYWORDS: Brain mapping, Brain, Photostimulation, Optogenetics, Neural networks, Mouth, Motion models, Electronics, Cameras, Animal model studies

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Proceedings Article | 17 March 2023 Presentation

5-HT2A receptor agonism modifies neurovascular coupling and neuronal network activity in mice

Jonah Padawer-Curry, Joshua Siegel, Anmol Jarang, Ginger Nicol, Jordan McCall, Adam Bauer

Proceedings Volume PC12365, PC1236505 (2023) https://doi.org/10.1117/12.2648386

KEYWORDS: Receptors, Neurovascular coupling, Hemodynamics, Brain, Neuroimaging, Calcium

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Proceedings Article | 28 April 2022 Presentation

Dual fluorophore imaging combined with optical intrinsic signal to acquire neural, metabolic and hemodynamic activity

Xiaodan Wang, Annie Bice, Jonah Padawer-Curry, Zachary Rosenthal, Jin-Moo Lee, Adam Bauer

Proceedings Volume PC11946, PC119460L (2022) https://doi.org/10.1117/12.2609860

KEYWORDS: Hemodynamics, Optical imaging, Calcium, Imaging systems, Visualization, Tissues, Scattering, Optogenetics, Optical circuits, Neurovascular coupling

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Proceedings Article | 7 March 2022 Presentation

Integrated light-based motor mapping with deep neural networks for tracking multiple limb movements in mice

Jonah Padawer-Curry, Adam Bauer, Nischal Khanal

Proceedings Volume PC11947, PC119470A (2022) https://doi.org/10.1117/12.2610258

KEYWORDS: Brain mapping, Neural networks, Brain, Photostimulation, Optogenetics, Mouth, Motion models, Electronics, Cameras, Animal model studies

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Proceedings Article | 5 March 2021 Presentation

Wide-field optical imaging along the neurovascular coupling pathway

Xiaodan Wang, Annie Bice, Zachary Rosenthal, Jin-Moo Lee, Adam Bauer

Proceedings Volume 11629, 1162920 (2021) https://doi.org/10.1117/12.2577739

KEYWORDS: Optical imaging, Neurovascular coupling, Calcium, Imaging systems, Hemodynamics, Visualization, Tissues, Scattering, Optogenetics, Optical circuits

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Proceedings Article | 5 March 2021 Presentation

Automated light-based motor mapping of multiple limb movements in mice using deep neural networks

Nischal Khanal, Kevin Schulte, Trevor Voss, Jonah Padawer-Curry, Byungchan Kim, Annie Bice, Adam Bauer

Proceedings Volume 11629, 116290O (2021) https://doi.org/10.1117/12.2578860

KEYWORDS: Neural networks, Brain mapping, Brain, Optogenetics, Mouth, Motion models, Motion estimation, Electronics, Cameras, Animal model studies

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Proceedings Article | 9 March 2020 Presentation

Functional connectivity predicts behavior deficit in a mouse model of brain tumor growth (Conference Presentation)

Inema Orukari, Nicole Warrington, Adam Bauer, Joshua Rubin, Joseph Culver

Proceedings Volume 11225, 1122506 (2020) https://doi.org/10.1117/12.2556218

KEYWORDS: Tumors, Brain, Mouse models, Magnetic resonance imaging, Neuroimaging, Modulation, Nervous system, Human subjects, Optical imaging, Sensors

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Tumors in the central nervous system (CNS) can produce significant behavior deficits. These deficits significantly reduce the quality of life of long-term brain tumor survivors. Motor deficits can be the main presenting symptoms that brings a brain tumor patient into the hospital. Additionally, motor deficits can either improve or worsen after treatment. Its poorly understood how tumor phenotype (e.g infiltrative or circumscribed) contributes to the development and evolution of motor deficits. Resting state functional connectivity magnetic resonance imaging (rsfc-MRI) could help determine a relationship between brain function and tumor phenotype. rsfc-MRI provides measurements of functional connectivity (FC), which is a measure of brain activity and has been shown to correlate with neurological function (e.g. cognitive and motor deficit) in many disease states. Additional studies are needed before rsfc-MRI can be included in the standard of care for brain tumor patients because it is largely unknown how important clinical factors, such as tumor location and tumor burden (e.g. tumor volume), modulate the association between FC measurements and neurological performance. However, human studies are unlikely to have the statistical power to determine the relationships between FC, clinical factors, and neurological function because it is difficult to enroll many human subjects while controlling for a factor. Fortunately, mice can be used to control for a factor in many genetically identical specimens. Therefore, FC assessments need to be applied to studies in mouse models of brain tumors to assess the interactions be specific clinical factors, FC measurements and neurological function. FC measurements are infrequently obtained in mouse models because it is technically difficult to perform rsfc-MRI on the small mouse brain. Fortunately, functional connectivity optical intrinsic signal imaging (fcOISI) can be used obtain FC measurements in mice. In this study, we investigated how tumor phenotype modulates the relationship between tumor burden measures and motor function. We injected in two groups of mice with human brain tumor cell lines that exhibit different growth phenotypes. We assessed the motor function of the mice by their performance on a battery of sensorimotor tests. We determined tumor burden with bioluminescence and MRI and assessed FC with fcOISI. Lastly, we performed linear regression analysis to determine how these measured factors interact in the prediction of performance on the motor tests.

SPIE Journal Paper | 13 July 2019 Open Access

Separability of calcium slow waves and functional connectivity during wake, sleep, and anesthesia

Lindsey Brier, Eric Landsness, Abraham Snyder, Patrick Wright, Grant Baxter, Adam Bauer, Jin-Moo Lee, Joseph Culver

NPh, Vol. 6, Issue 03, 035002, (July 2019) https://doi.org/10.1117/12.10.1117/1.NPh.6.3.035002

KEYWORDS: Brain, Calcium, Electroencephalography, Brain mapping, Principal component analysis, Binary data, Video, Modulation, Luminescence, Neurophotonics

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Proceedings Article | 4 March 2019 Presentation

A diffuse optical tomography system for whole-brain functional imaging in mice using multiple camera views (Conference Presentation)

Zachary Markow, Matthew Reisman, Adam Bauer, Adam Eggebrecht, Mark Anastasio, Joseph Culver

Proceedings Volume 10874, 108741G (2019) https://doi.org/10.1117/12.2508997

KEYWORDS: Imaging systems, Diffuse optical tomography, Cameras, Functional imaging, Head, Digital micromirror devices, 3D metrology, Profiling, Natural surfaces, Neuroimaging

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Proceedings Article | 19 April 2017 Presentation

Contralesional homotopic activity negatively influences functional recovery after stroke (Conference Presentation)

Adam Bauer, Andrew Kraft, Grant Baxter, Michael Bruchas, Jin-Moo Lee, Joseph Culver

Proceedings Volume 10052, 100520P (2017) https://doi.org/10.1117/12.2253719

KEYWORDS: Somatosensory cortex, Ischemic stroke, Medicine, Optical manipulation, Current controlled current source, Optogenetics, Brain, Neurons, Tissues, Tissue optics

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Proceedings Article | 19 April 2017 Presentation

Mapping cell-specific functional connections in the mouse brain using ChR2-evoked hemodynamics (Conference Presentation)

Adam Bauer, Andrew Kraft, Grant Baxter, Michael Bruchas, Jin-Moo Lee, Joseph Culver

Proceedings Volume 10051, 100510Y (2017) https://doi.org/10.1117/12.2253100

KEYWORDS: Medicine, Integrated optics, Optical imaging, Brain mapping, Hemodynamics, Optogenetics, Brain, Neuroimaging, Functional magnetic resonance imaging, Neurons

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Functional magnetic resonance imaging (fMRI) has transformed our understanding of the brain’s functional organization. However, mapping subunits of a functional network using hemoglobin alone presents several disadvantages. Evoked and spontaneous hemodynamic fluctuations reflect ensemble activity from several populations of neurons making it difficult to discern excitatory vs inhibitory network activity. Still, blood-based methods of brain mapping remain powerful because hemoglobin provides endogenous contrast in all mammalian brains. To add greater specificity to hemoglobin assays, we integrated optical intrinsic signal(OIS) imaging with optogenetic stimulation to create an Opto-OIS mapping tool that combines the cell-specificity of optogenetics with label-free, hemoglobin imaging. Before mapping, titrated photostimuli determined which stimulus parameters elicited linear hemodynamic responses in the cortex. Optimized stimuli were then scanned over the left hemisphere to create a set of optogenetically-defined effective connectivity (Opto-EC) maps. For many sites investigated, Opto-EC maps exhibited higher spatial specificity than those determined using spontaneous hemodynamic fluctuations. For example, resting-state functional connectivity (RS-FC) patterns exhibited widespread ipsilateral connectivity while Opto-EC maps contained distinct short- and long-range constellations of ipsilateral connectivity. Further, RS-FC maps were usually symmetric about midline while Opto-EC maps displayed more heterogeneous contralateral homotopic connectivity. Both Opto-EC and RS-FC patterns were compared to mouse connectivity data from the Allen Institute. Unlike RS-FC maps, Thy1-based maps collected in awake, behaving mice closely recapitulated the connectivity structure derived using ex vivo anatomical tracer methods. Opto-OIS mapping could be a powerful tool for understanding cellular and molecular contributions to network dynamics and processing in the mouse brain.

Proceedings Article | 19 April 2017 Presentation

An optical assessment of the effects of glioma growth on resting state networks in mice (Conference Presentation)

Inema Orukari, Adam Bauer, Grant Baxter, Joshua Rubin, Joseph Culver

Proceedings Volume 10051, 100510P (2017) https://doi.org/10.1117/12.2252817

KEYWORDS: Tumors, Current controlled current source, Brain, Optical imaging, Mouse models, Somatosensory cortex, Magnetic resonance imaging, Bioluminescence

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SPIE Journal Paper | 13 April 2017 Open Access

Structured illumination diffuse optical tomography for noninvasive functional neuroimaging in mice

Matthew Reisman, Zachary Markow, Adam Bauer, Joseph Culver

NPh, Vol. 4, Issue 02, 021102, (April 2017) https://doi.org/10.1117/12.10.1117/1.NPh.4.2.021102

KEYWORDS: Sensors, Data modeling, Imaging systems, Brain, Neuroimaging, Diffuse optical tomography, Head, Cameras, Optical properties, Tissues

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Proceedings Article | 3 March 2014 Paper

Resting-state functional connectivity imaging of the mouse brain using photoacoustic tomography

Mohammadreza Nasiriavanaki, Jun Xia, Hanlin Wan, Adam Bauer, Joseph Culver, Lihong Wang

Proceedings Volume 8943, 89432O (2014) https://doi.org/10.1117/12.2036606

KEYWORDS: Photoacoustic tomography, Brain, Neuroimaging, Spatial resolution, Functional magnetic resonance imaging, Tissue optics, Optical imaging, Brain mapping, Imaging systems, Signal to noise ratio

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Proceedings Article | 28 February 2012 Paper

Fluorescence goggle for intraoperative breast cancer imaging

Yang Liu, Adam Bauer, Walter Akers, Gail Sudlow, Kexian Liang, Tauseef Charanya, Suman Mondal, Joseph Culver, Samuel Achilefu

Proceedings Volume 8215, 82150G (2012) https://doi.org/10.1117/12.910509

KEYWORDS: Tumors, Luminescence, Goggles, Tissues, Near infrared, Breast cancer, Surgery, Imaging systems, Visualization, Laser safety equipment

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SPIE Journal Paper | 1 September 2011 Open Access

Quantitative photoacoustic imaging: correcting for heterogeneous light fluence distributions using diffuse optical tomography

Adam Bauer, Ralph Nothdurft, Joseph Culver, Todd Erpelding, Lihong Wang

JBO, Vol. 16, Issue 09, 096016, (September 2011) https://doi.org/10.1117/12.10.1117/1.3626212

KEYWORDS: Absorption, Scattering, Capillaries, Optical properties, Imaging systems, Photoacoustic imaging, Tissue optics, Diffuse optical tomography, Photoacoustic spectroscopy, Light scattering

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Proceedings Article | 28 February 2011 Paper

Quantitative high-resolution photoacoustic spectroscopy by combining photoacoustic imaging with diffuse optical tomography

Adam Bauer, Ralph Nothdurft, Todd Erpelding, Lihong Wang, Joseph Culver

Proceedings Volume 7899, 78993O (2011) https://doi.org/10.1117/12.875549

KEYWORDS: Acquisition tracking and pointing, Absorption, Photoacoustic spectroscopy, Diffuse optical tomography, Capillaries, Error analysis, Optical properties, Photoacoustic imaging, Ultrasonography, Imaging systems

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Proceedings Article | 12 February 2011 Paper

Compact intraoperative imaging device for sentinel lymph node mapping

Yang Liu, Adam Bauer, Walter Akers, Gail Sudlow, Kexian Liang, Duanwen Shen, Mikhail Berezin, Joseph Culver, Samuel Achilefu

Proceedings Volume 7910, 79100D (2011) https://doi.org/10.1117/12.886226

KEYWORDS: Lymphatic system, Near infrared, Luminescence, Imaging devices, Surgery, Cancer, Sensors, Light sources, Imaging systems, Tissues

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Showing 5 of 19 publications

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