Dr. Adrien Ponticorvo Profile

Dr. Adrien Ponticorvo

Project Scientist at Beckman Laser Institute and Medical Clinic

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Publications (18)

SPIE Journal Paper | March 15, 2018

Correcting for motion artifact in handheld laser speckle images

Lertsakdadet, Ben , Yang, Bruce , Dunn, Cody , Ponticorvo, Adrien , Crouzet, Christian , Bernal, Nicole , Durkin, Anthony , Choi, Bernard

JBO Vol. 23 Issue 03

KEYWORDS: Fermium, Frequency modulation, Speckle, Blood circulation, Data acquisition, Motion measurement, In vivo imaging, In vitro testing, Laser speckle imaging, Imaging systems

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PROCEEDINGS ARTICLE | March 14, 2018

Spatial frequency domain imaging tracks healing following split-thickness skin grafts of burn wounds (Conference Presentation)

Proc. SPIE. 10467, Photonics in Dermatology and Plastic Surgery 2018

KEYWORDS: Wound healing, Optical properties, Tissues, Scattering, Skin, Oxygen, In vivo imaging, Tissue optics, Absorption, Diffuse optical imaging

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PROCEEDINGS ARTICLE | February 14, 2018

Assessing the predictive capability of optical imaging techniques, Spatial Frequency Domain Imaging (SFDI) and Laser Speckle Imaging (LSI), to the gold standard of clinical assessment in a controlled animal model

Proc. SPIE. 10467, Photonics in Dermatology and Plastic Surgery 2018

KEYWORDS: Wound healing, Modulation, Optical properties, Tissues, Scattering, Skin, Remote sensing, Laser speckle imaging, Animal model studies

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The current standard for assessment of burn severity and subsequent wound healing is through clinical examination, which is highly subjective. Accurate early assessment of burn severity is critical for dictating the course of wound management. Complicating matters is the fact that burn wounds are often large and can have multiple regions that vary in severity. In order to manage the treatment more effectively, a tool that can provide spatially resolved information related to mapping burn severity could aid clinicians when making decisions. Several new technologies focus on burn care in an attempt to help clinicians objectively determine burn severity. By quantifying perfusion, laser speckle imaging (LSI) has had success in categorizing burn wound severity at earlier time points than clinical assessment alone. Additionally, spatial frequency domain imaging (SFDI) is a new technique that can quantify the tissue structural damage associated with burns to achieve earlier categorization of burn severity. Here we compared the performance of a commercial LSI device (PeriCam PSI, Perimed Inc.), a SFDI device (Reflect RS^TM, Modulated Imaging Inc.) and conventional clinical assessment in a controlled (porcine) model of graded burn wound severity over the course of 28 days. Specifically we focused on the ability of each system to predict the spatial heterogeneity of the healed wound at 28 days, based on the images at an early time point. Spatial heterogeneity was defined by clinical assessment of distinct regions of healing on day 28. Across six pigs, 96 burn wounds (3 cm diameter) were created. Clinical assessment at day 28 indicated that 39 had appeared to heal in a heterogeneous manner. Clinical observation at day 1 found 35 / 39 (90%) to be spatially heterogeneous in terms of burn severity. The LSI system was able to detect spatial heterogeneity of burn severity in 14 / 39 (36%) cases on day 1 and 23 / 39 cases (59%) on day 7. By contrast the SFDI system was able to detect spatial heterogeneity of burn severity in 39 / 39 (100%) cases on day 1. Here we have demonstrated that for the purposes of predicting heterogeneity in wound healing, SFDI generated scattering properties were a significantly more effective tool than perfusion images measured using LSI. This indicates that SFDI may be better suited to help clinicians categorize different burns earlier, ultimately informing treatment strategy to improve patient outcomes.

SPIE Journal Paper | July 20, 2017

Solid tissue simulating phantoms having absorption at 970 nm for diffuse optics

Kennedy, Gordon , Lentsch, Griffin , Trieu, Brandon , Ponticorvo, Adrien , Saager, Rolf , Durkin, Anthony

JBO Vol. 22 Issue 07

KEYWORDS: Tissue optics, Solids, Tissues, Absorption, Diffuse optical imaging, Scattering, Optical simulations, Optical components, Luminescence, Chromophores

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PROCEEDINGS ARTICLE | May 1, 2017

Bio-optic signatures for advanced glycation end products in the skin in streptozotocin (STZ) Induced Diabetes (Conference Presentation)

Proc. SPIE. 10060, Optical Biopsy XV: Toward Real-Time Spectroscopic Imaging and Diagnosis

KEYWORDS: Proteins, Glucose, Medical laser equipment, Multiphoton microscopy, Nerve, Tissues, Blood, Skin, Collagen, Biopsy

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PROCEEDINGS ARTICLE | March 14, 2017

Design and fabrication of solid phantoms for NIR water fraction studies

Proc. SPIE. 10056, Design and Quality for Biomedical Technologies X

KEYWORDS: Near infrared, Biomedical optics, Optical properties, Tissues, Scattering, Water, Silicon, Tissue optics, Absorption, Diffuse optical imaging

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PROCEEDINGS ARTICLE | February 6, 2017

Quantitative assessment of graded burn wounds using a commercial and research grade laser speckle imaging (LSI) system

Proc. SPIE. 10037, Photonics in Dermatology and Plastic Surgery

KEYWORDS: Wound healing, Injuries, Doppler effect, Tissues, Surgery, Imaging systems, Speckle, Dermatology, Optical inspection, Laser speckle imaging, Photonics, Blood circulation, Analytical research, RGB color model

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PROCEEDINGS ARTICLE | April 27, 2016

Quantitative long term measurements of burns in a rat model using spatial frequency domain imaging and laser speckle imaging (Conference Presentation)

Proc. SPIE. 9711, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX

KEYWORDS: Wound healing, Injuries, Visualization, Scattering, Biopsy, Optical inspection, Inflammation, Laser speckle imaging, Speckle imaging, Scatter measurement

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PROCEEDINGS ARTICLE | April 26, 2016

Low-cost tissue simulating phantoms with tunable, wavelength-dependent scattering properties (Conference Presentation)

Proc. SPIE. 9700, Design and Quality for Biomedical Technologies IX

KEYWORDS: Near infrared, Visible radiation, Optical properties, Tissues, Scattering, Particles, Laser scattering, Mie scattering, Tissue optics, Laser tissue interaction

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SPIE Journal Paper | October 12, 2015

Differential pathlength factor informs evoked stimulus response in a mouse model of Alzheimer’s disease

Lin, Alexander , Ponticorvo, Adrien , Durkin, Anthony , Venugopalan, Vasan , Choi, Bernard , Tromberg, Bruce

NPh Vol. 2 Issue 04

KEYWORDS: Brain, Optical properties, Oxygen, Mouse models, Scattering, Absorption, Hemodynamics, Neuroimaging, Near infrared, Reflectivity

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SPIE Journal Paper | September 24, 2013

Laser speckle contrast imaging of blood flow in rat retinas using an endoscope

Ponticorvo, Adrien , Cardenas, Damon , Dunn, Andrew , Ts'o, Daniel , Duong, Timothy

JBO Vol. 18 Issue 09

KEYWORDS: Blood circulation, Laser speckle contrast imaging, Retina, Endoscopes, Visualization, Speckle, Reflectivity, Cornea, Eye, Hyperoxia

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SPIE Journal Paper | September 4, 2013

Visible spatial frequency domain imaging with a digital light microprojector

Lin, Alexander , Ponticorvo, Adrien , Konecky, Soren , Cui, Haotian , Rice, Tyler , Choi, Bernard , Durkin, Anthony , Tromberg, Bruce

JBO Vol. 18 Issue 09

KEYWORDS: Tissue optics, Scattering, Absorption, Spectrophotometry, Skull, Brain, Spatial frequencies, Projection systems, Optical properties, Cameras

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SPIE Journal Paper | June 13, 2013

Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity

Nguyen, John Quan , Crouzet, Christian , Mai, Tuan , Riola, Kathleen , Uchitel, Daniel , Liaw, Lih-Huei , Bernal, Nicole , Ponticorvo, Adrien , Choi, Bernard , Durkin, Anthony

JBO Vol. 18 Issue 06

KEYWORDS: Scattering, Injuries, Tissue optics, Tissues, Blood, Chromophores, Optical properties, Visualization, Skin, Oxygen

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PROCEEDINGS ARTICLE | March 8, 2013

Quantitative longitudinal measurement in a rat model of controlled burn severity using spatial frequency domain imaging

Proc. SPIE. 8565, Photonic Therapeutics and Diagnostics IX

KEYWORDS: Optical imaging, Wound healing, Injuries, Optical properties, Tissues, Skin, Optical microscopy, Oxygen, Chromophores, Laser tissue interaction

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PROCEEDINGS ARTICLE | February 9, 2012

Monte Carlo simulation of fluorescence imaging of microvasculature

Proc. SPIE. 8221, Optical Interactions with Tissue and Cells XXIII

KEYWORDS: Confocal microscopy, Optical properties, Tissues, Cameras, Sensors, Luminescence, 3D modeling, Monte Carlo methods, Signal detection, Absorption

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PROCEEDINGS ARTICLE | February 18, 2010

Spatial mapping of oxygen levels in the brain using a digital micromirror device

Proc. SPIE. 7596, Emerging Digital Micromirror Device Based Systems and Applications II

KEYWORDS: Speckle, Cameras, Oxygen, Phosphorescence, Temporal resolution, Blood circulation, Digital micromirror devices, In vivo imaging, Brain mapping, Brain

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PROCEEDINGS ARTICLE | February 20, 2008

Enhancement of light in tissue using hyper-osmotic agents

Proc. SPIE. 6854, Optical Interactions with Tissue and Cells XIX

KEYWORDS: Veins, Speckle, Blood, Blood vessels, Capillaries, Skin, Arteries, Blood circulation, Tissue optics, Doppler tomography

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PROCEEDINGS ARTICLE | February 16, 2007

Imaging Hemodynamic Effects of ET-1 on Cerebral Blood Flow in Rats

Proc. SPIE. 6446, Biomedical Applications of Light Scattering

KEYWORDS: Ischemia, Doppler effect, Speckle, Laser speckle contrast imaging, Temporal resolution, Blood circulation, Hemodynamics, Cerebral blood flow, Spatial resolution, Animal model studies

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Showing 5 of 18 publications

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