Photonic Crystal Fibers (PCFs) have special structures and offer a number of novel design options, such as very large or very small mode areas, high numerical aperture, guidance of light in air, and novel dispersion properties. PCFs have become an attractive field for the researchers and they are trying to work on these to get their properties applied in dispersion related applications, sensing applications and much more. PCFs sensors are widely used in bio-medical applications. The sensitivity and performance of sensors are enhanced due to novel applications of PCFs. This paper outlines a novel design for a generalized biomedical sensor by collaborating PCF and electro-optic effect of Lithium Niobate (<i>LiNbO<sub>3</sub></i>) based Mach-Zehnder interferometer (MZI) structure.