Laser induced breakdown spectroscopy (LIBS) has been used to distinguish normal and malignant tumor cells from histological sections. LIBS measures concentrations of trace elements directly in real-time. It has been observed that the concentration of trace elements in normal and the tumor cells vary significantly. This technique can be incorporated with laser scalpel to monitor the cancer affected area during the surgery. LIBS spectrum of hair and nail has also been recorded. This technique has potential to be an automated, real-time diagnostic procedure for cancer that would greatly facilitate their diagnosis and classification.
The motivation of this work is to monitor the real time concentration of nitrates in the radioactive wastes, as they are the key molecules in the solution. The effect of different optical configurations of the probes on the Raman signal was studied using acetone as the test sample. We found that InPhotonicsTM Raman probe give best signal-to-noise data comparing to the other two probes evaluated. The Raman spectra of 10% NaNO3 solution were then successfully recorded with this probe. The Raman signal of Nitrate at 1054 cm-1 is very strong with 500 ms sampling time. The initial study shows that the Raman sensor is capable to monitor the nitrate in the nuclear waste tank.