There us a significant need for point of care pathology technologies that provide microscopic resolution without the processing that is typically required. 20,000,000 biopsies per year in the USA each present a week delay in cancer care while they are processed and analyzed. Bedside confocal microscopy offers an alternative but has typically been difficult to perform due to the irregularity of surgical specimens and reflectance artifact. The sample irregularity makes it hard to put the correct plane of tissue in the conjugate focal plane and the reflectance artifact that arises from the glass/water interface at the window surface onto which the sample is pressed, gives the appearance of tissue outside the specimen (where there is no tissue, false positive for tissue). We present newly developed computational and electromechanical solutions to these problems and analysis of specimens under our clinical research study.