The paper presents the results of an in-vivo study of lymphedema tissue by optical coherent elastography in small animals. A lower limb lymphedema model in Wistar rats by lymph node resection was created. This article describes the application of the method of optical coherent elastography as a tool for in-vivo study of a model of lower limb lymphedema in small laboratory animals. Studies have shown that with the development of lymphedema, elastic properties change significantly.
The quasi-static compression optical coherence elastography (OCE) is used to find Young’s modulus of human skin1,2 . The data on the layers of human skin deformation in vivo were obtained and analyzed. In the OCE compression method, a calibration layer with a known Young's modulus was used, which made it possible to identify the value of the volunteers' skin elastic modulus.
The changes in the stiffness modulus of collagen structures in a collagen phantom were studied using optical coherent elastography (OCE). The disorganization of the phantom collagen fibers was obtained by mechanical action (twisting). Young's modulus values were measured for various phantom density values using the compression OCE method.